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Article
Open AccessExperimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression
Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10% in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and scarce knowledge of the biological...
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Article
Open AccessCorrection to: Orthotopic model of lung cancer: isolation of bone micro-metastases after tumor escape from Osimertinib treatment
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Article
Open AccessOrthotopic model of lung cancer: isolation of bone micro-metastases after tumor escape from Osimertinib treatment
Osimertinib is a third generation tyrosine kinase inhibitor (TKI) that targets the epidermal growth factor receptor (EGFR) in lung cancer. However, although this molecule is not subject to some of the resistan...
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Article
Open AccessDeciphering the complex role of thrombospondin-1 in glioblastoma development
We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to ...
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Article
Disrupting the CD95–PLCγ1 interaction prevents Th17-driven inflammation
CD95L is a transmembrane ligand (m-CD95L) that is cleaved by metalloproteases to release a soluble ligand (s-CD95L). Unlike m-CD95L, interaction between s-CD95L and CD95 fails to recruit caspase-8 and FADD to ...
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Article
Open AccessHigh epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor
Epidermal growth factor (EGF) receptors contribute to the development of malignant glioma. Here we considered the possible implication of the EGFR ligand epiregulin (EREG) in glioma development in relation to ...
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Article
Functional histology of glioma vasculature by FTIR imaging
Fourier-transform infrared (FTIR) imaging has been used to investigate brain tumor angiogenesis using a mice solid tumor model and bare-gold (∅ 25 nm) or BaSO4 (∅ 500 nm) nanoparticles (NP) injected into blood va...
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Article
Detection of collagens in brain tumors based on FTIR imaging and chemometrics
Fourier transform infrared (FTIR) imaging has been used as a molecular histopathology tool on brain tissue sections after intracranial implantation and development of glioma tumors. Healthy brain tissue (contr...
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Article
Inhibition of FGF receptor activity in glioma implanted into the mouse brain using the tetracyclin-regulated expression system
We have investigated growth and vascularization of malignant glioma in mice upon conditional inhibition of fibroblast growth factor (FGF) receptor activity. C6 rat glioma cells were transfected with a dominant...
