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    Article

    Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation

    Combined therapy with anti-BRAF plus anti-MEK is currently used as first-line treatment of patients with metastatic melanomas harboring the somatic BRAF V600E mutation. However, the main issue with targeted thera...

    Margaux Sala, Nathalie Allain, Mélanie Moreau, Arnaud Jabouille, Elodie Henriet in Oncogene (2022)

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    Article

    Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma

    Lineage-tracing experiments in the mouse show that Lgr6, but not Lgr5, functions as a cancer stem marker in skin squamous cell carcinomas (SCCs). The authors also show that Lgr6-knockout mice are predisposed to S...

    Phillips Y Huang, Eve Kandyba, Arnaud Jabouille, Jonas Sjolund in Nature Genetics (2017)

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    Open Access

    High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor

    Epidermal growth factor (EGF) receptors contribute to the development of malignant glioma. Here we considered the possible implication of the EGFR ligand epiregulin (EREG) in glioma development in relation to ...

    Gregor Auf, Arnaud Jabouille, Maylis Delugin, Sylvaine Guérit, Raphael Pineau in BMC Cancer (2013)