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Open AccessExperimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression
Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10% in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and scarce knowledge of the biological...
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Open AccessPlk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma
Polo-like kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 expression are poorly understood. Here, we uncover a hypo...
