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Chapter and Conference Paper
Smooth Attention for Deep Multiple Instance Learning: Application to CT Intracranial Hemorrhage Detection
Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag...
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Chapter and Conference Paper
Crowdsourcing Segmentation of Histopathological Images Using Annotations Provided by Medical Students
Segmentation of histopathological images is an essential task for cancer diagnosis and prognosis in computational pathology. Unfortunately, Machine Learning (ML) techniques need large labeled datasets to train...
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Chapter and Conference Paper
A Robust BKSVD Method for Blind Color Deconvolution and Blood Detection on H &E Histological Images
Hematoxylin and Eosin (H &E) color variation between histological images from different laboratories degrades the performance of Computer-Aided Diagnosis systems. Histology-specific models to solve color varia...
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Chapter and Conference Paper
Learning AnalyTICs: Exploring the Hypothetical Learning Trajectories Through Mathematical Games
Current conditions limit the direct observation of learning processes useful for teachers design the hypothetical learning trajectories. Fortunately, technology makes it possible to complement direct observati...
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Chapter
Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome
The essential membrane complex FtsE/FtsX (FtsEX), belonging to the ABC transporter superfamily and widespread among bacteria, plays a relevant function in some crucial cell wall remodeling processes such as ce...
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Article
Open AccessLearning from crowds in digital pathology using scalable variational Gaussian processes
The volume of labeled data is often the primary determinant of success in develo** machine learning algorithms. This has increased interest in methods for leveraging crowds to scale data labeling efforts, an...
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Article
Operational tool for characterizing high-frequency sea level oscillations
The progressive upgrade of tide gauges to match tsunami warning requirements, tied with an upgrade of tide gauges with 1-min or less sampling and latency, has led to a huge amount of data available worldwide f...
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Chapter and Conference Paper
Combining Attention-Based Multiple Instance Learning and Gaussian Processes for CT Hemorrhage Detection
Intracranial hemorrhage (ICH) is a life-threatening emergency with high rates of mortality and morbidity. Rapid and accurate detection of ICH is crucial for patients to get a timely treatment. In order to achi...
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Article
Molecular characterization of spiny hedgehogs of the Iberian Peninsula: the missing link in the postglacial colonization of the western European hedgehog
The western European hedgehog Erinaceus europaeus is the most representative species among spiny Iberian hedgehogs. The Algerian hedgehog Atelerix algirus and the four-toed hedgehog Atelerix albiventris are other...
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Article
Modulation of the acidity of a vermiculite and its potential use as a catalytic support
The modulation and characterization of the acidity of a vermiculite were carried out, which was modified by delamination by means of hydrothermal and acid treatments with the subsequent incorporation of AlZr a...
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Article
Open AccessStructure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
Type III CRISPR-Cas multisubunit complexes cleave ssRNA and ssDNA. These activities promote the generation of cyclic oligoadenylate (cOA), which activates associated CRISPR-Cas RNases from the Csm/Csx families...
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Chapter and Conference Paper
Classifying Prostate Histological Images Using Deep Gaussian Processes on a New Optical Density Granulometry-Based Descriptor
The increasing use of whole slide digital scanners has led to an enormous interest in the application of machine learning techniques to detect prostate cancer using eosin and hematoxylin stained histopathologi...
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Article
Open AccessUnderstanding the indirect DNA read-out specificity of I-CreI Meganuclease
The high DNA specificity of homing endonucleases makes them a powerful protein scaffold to engineer enzymes for genome manipulation. Understanding their molecular recognition of DNA is an important prerequisit...
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Chapter and Conference Paper
Fully Automated Blind Color Deconvolution of Histopathological Images
Most whole-slide histological images are stained with hematoxylin and eosin dyes. Slide stain separation or color deconvolution is a crucial step within the digital pathology workflow. In this paper, the blind...
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Chapter and Conference Paper
Hard Exudate Detection Using Local Texture Analysis and Gaussian Processes
Exudates are the most noticeable sign in the first stage of diabetic retinopathy. This disease causes about five percent of world blindness. Making use of retinal fundus images, exudates can be detected, which...
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Article
Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI
I-DmoI, from the hyperthermophilic archaeon Desulfurococcus mobilis, belongs to the LAGLIDADG homing endonuclease protein family. Its members are highly specific enzymes capable of recognizing long DNA target seq...
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Article
Open AccessEvaluation of two strategies for the interpretation of tumour markers in pleural effusions
Pleural effusions present a diagnostic challenge. Approximately 20% are associated with cancer and some 50% require invasive procedures to perform diagnosis. Determination of tumour markers may help to identif...
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Article
Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair
The intrinsically disordered protein p15PAF regulates DNA replication and repair by binding to the proliferating cell nuclear antigen (PCNA) sliding clamp. We present the structure of the human p15PAF–PCNA comple...
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Article
Visualizing phosphodiester-bond hydrolysis by an endonuclease
Different catalytic steps of endonuclease I-DmoI are captured crystallographically to allow direct observation of the generation of a DNA double-strand break. A third metal ion enters the active site and has a...
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Article
EDTA-Ce(III) Modified Pt Vulcan XC-72 Catalyst Synthesis for Methanol Oxidation in Acid Solution
Cerium modified Pt nanoparticles catalysts have been prepared using Ce(III)-ethylenediaminetetraacetic acid (EDTA) chemistry with an impregnation method of 20 % Pt/Carbon Vulcan XC-72. EDTA was used as a chela...
