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Article
Open AccessIbrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling
Osimertinib, a 3rd generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is the first-line standard-of-care for EGFR-mutant non-small cell lung cancer (NSCLC) patients, while acquir...
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Article
CRISPR-Cas adaptive immune systems in Sulfolobales: genetic studies and molecular mechanisms
CRISPR-Cas systems provide the small RNA-based adaptive immunity to defend against invasive genetic elements in archaea and bacteria. Organisms of Sulfolobales, an order of thermophilic acidophiles belonging t...
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Article
Metformin attenuates TGF-β1-induced pulmonary fibrosis through inhibition of transglutaminase 2 and subsequent TGF-β pathways
The purpose of this study was to confirm whether metformin can attenuate TGF-β1-induced pulmonary fibrosis through inhibition of transglutaminase 2 (TG2) and subsequent TGF-β pathways. In vitro, MTT assay and ...
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Article
Open AccessCharacterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase
Antiviral defense by type III CRISPR-Cas systems relies on two distinct activities of their effectors: the RNA-activated DNA cleavage and synthesis of cyclic oligoadenylate. Both activities are featured as ind...
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Article
Open AccessMetformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1
Alectinib is a second-generation anaplastic lymphoma kinase (ALK) inhibitor that has sufficient clinical efficacy and satisfactory safety in ALK-positive non-small cell lung cancer (NSCLC) patients with or wit...
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Article
Open AccessStructure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
Type III CRISPR-Cas multisubunit complexes cleave ssRNA and ssDNA. These activities promote the generation of cyclic oligoadenylate (cOA), which activates associated CRISPR-Cas RNases from the Csm/Csx families...
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Chapter and Conference Paper
Numerical Study on Behavior of Top-Blown Supersonic Jets and Their Interaction with Bath in BOF Steelmaking Convertor
A three-dimensional transient CFD model combined VOF interface tracking technique for compressible supersonic oxygen-jets im**ing on the free surface of molten slag/metal is developed. Jets behavior at steel...
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Chapter
Determination of Cavity Profile Induced by Supersonic Jets Im**ing Onto Liquids Surface
The im**ement onto the surface of bath by top-blown jets is a significant process characteristic in BOF and EAF steelmaking process. The cavity is one of the most important outcomes of the interaction and pl...
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Chapter and Conference Paper
A Statistics Based Prediction Method for Rendering Application
As an interesting commercial application, rendering plays an important role in the field of animation and movie production. Generally, render farm is used to rendering mass images concurrently according to the...
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Chapter
Computational Investigation of Splashing Behaviors in Steelmaking Converter
Splashing plays a key role in the kinetics of the steelmaking converter but not well understood. This work presents a numerical investigation on the generation of the splashing and introduces an evaluation app...
