10 Result(s)
within
R Scott Hawley
Life Sciences
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Article
Open AccessGenetic background impacts the timing of synaptonemal complex breakdown in Drosophila melanogaster
Experiments performed in different genetic backgrounds occasionally exhibit failure in experimental reproducibility. This is a serious issue in Drosophila where there are no standard control stocks. Here, we illu...
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Article
Combined expansion microscopy with structured illumination microscopy for analyzing protein complexes
Biologists have long been fascinated with the organization and function of intricate protein complexes. Therefore, techniques for precisely imaging protein complexes and the location of proteins within these c...
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Article
Regulating the construction and demolition of the synaptonemal complex
The synaptonemal complex (SC) connects homologous chromosomes in meiotic prophase, thus promoting genetic exchange and ensuring accurate chromosomal segregation at anaphase. In this Review, the authors discuss...
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Article
Homologue pairing: getting it right
In Caernorhabditis elegans, homologue pairing is mediated by specialized regions near one end of each chromosome in conjunction with zinc finger (ZnF)-bearing proteins. Families of repeated sequences that are enr...
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Chapter
Synapsis, Double-Strand Breaks, and Domains of Crossover Control in Drosophila Females
Drosophila is an attractive model system in which powerful tools in genetics and cytology can be used to identify and characterize the genes required for meiotic recombination. This ...
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Article
The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle
Mutations in the aberrant X segragation (Axs) gene disrupt the segregation of achiasmate chromosomes during female meiosis in Drosophila melanogaster. We show that Axs encodes the founding member of an eukaryotic...
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Article
Hanging on to your homolog: the roles of pairing, synapsis and recombination in the maintenance of homolog adhesion
Homologous chromosomes initially undergo weak alignments that bring homologous sequences into register during meiosis. These alignments can be facilitated by two types of mechanisms: interstitial homology sear...
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Article
mei-41 is required for precocious anaphase in Drosophila females
This paper reports on a new role for mei-41 in cell cycle control during meiosis. This function is revealed by the requirement of mei-41 for the precocious anaphase observed in crossover-defective mutants. Normal...
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Article
A structure-function analysis of NOD, a kinesin-like protein from Drosopbila melanogaster
We have analyzed a collection of 12 mutations in the Drosophila melanogaster nod locus, which encodes a kinesin-like protein involved in female meiotic chromosome segregation. The kinesin-like domain is at the N-...
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Chapter
Molecular Analysis of Insect Meiosis and Sex Ratio Distortion
It is arguable that gametogenesis is, if not preeminent, at least among the most critical processes in development. Errors in any other developmental system may result at worst in the genetic death of the indi...
