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Synapsis, Double-Strand Breaks, and Domains of Crossover Control in Drosophila Females

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Recombination and Meiosis

Part of the book series: Genome Dynamics and Stability ((GENOME,volume 2))

Abstract

Drosophila is an attractive model system in which powerful tools in genetics and cytology can be used to identify and characterize the genes required for meiotic recombination. This article reviews recent developments in understanding how pairing and synapsis proceed in the absence of double-strand breaks (DSBs), the relationship of DSB formation to synapsis, how crossovers are determined and formed, and the role that chromosome structure, including specialized sites, plays in regulating DSB formation and repair.

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Authors and Affiliations

  1. Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, 190 Frelinghuysen Rd., 08854, Piscataway, NJ, USA

    Sonam Mehrotra & Kim S. McKim

  2. Stowers Institute for Medical Research, 64110, Kansas City, MO, USA

    R. Scott Hawley

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  1. Sonam Mehrotra
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  2. R. Scott Hawley
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  3. Kim S. McKim
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Correspondence to Kim S. McKim .

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Richard Egel Dirk-Henner Lankenau

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Mehrotra, S., Hawley, R.S., McKim, K.S. (2007). Synapsis, Double-Strand Breaks, and Domains of Crossover Control in Drosophila Females. In: Egel, R., Lankenau, DH. (eds) Recombination and Meiosis. Genome Dynamics and Stability, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7050_2007_028

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