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  1. Article

    Open Access

    Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster

    Reproductive success requires the development of viable oocytes and the accurate segregation of chromosomes during meiosis. Failure to segregate chromosomes properly can lead to infertility, miscarriages, or d...

    Siqi Sun, Tyler Defosse, Ayla Boyd, Joel Sop, Faith Verderose… in Scientific Reports (2024)

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  2. No Access

    Article

    The chromosomal basis of meiotic acentrosomal spindle assembly and function in oocytes

    Several aspects of meiosis are impacted by the absence of centrosomes in oocytes. Here, we review four aspects of meiosis I that are significantly affected by the absence of centrosomes in oocyte spindles. One...

    Sarah J. Radford, Alexandra L. Nguyen, Karen Schindler, Kim S. McKim in Chromosoma (2017)

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    Protocol

    Cytological Analysis of Meiosis in Fixed Drosophila Ovaries

    Methods are described to analyze two different parts of the Drosophila ovary, which correspond to early stages (pachytene) and late stages (metaphase I and beyond) of meiosis. In addition to taking into account m...

    Kim S. McKim, Eric F. Joyce, Janet K. Jang in Meiosis (2009)

  4. No Access

    Chapter

    Synapsis, Double-Strand Breaks, and Domains of Crossover Control in Drosophila Females

    Drosophila is an attractive model system in which powerful tools in genetics and cytology can be used to identify and characterize the genes required for meiotic recombination. This ...

    Sonam Mehrotra, R. Scott Hawley, Kim S. McKim in Recombination and Meiosis (2008)

  5. Article

    Spindle assembly in the oocytes of mouse and Drosophila – similar solutions to a problem

    In the oocytes of many organisms a bipolar spindle is assembled in the absence of centrosomes. In this article we review how this occurs in two model organisms, Drosophila melanogaster and Mus musculus. Common th...

    Susan Doubilet, Kim S. McKim in Chromosome Research (2007)

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  6. No Access

    Article

    The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins

    Mutations in the unc-60 gene of the nematode Caenorhabditis elegans result in paralysis. The thin filaments of the muscle cells are severely disorganized and not bundled with myosin into functional contractile un...

    Kim S. McKim, Camela Matheson, Marco A. Marra… in Molecular and General Genetics MGG (1994)

  7. No Access

    Article

    Genetic and molecular analysis of thedpy-14 region inCaenorhabditis elegans

    Essential genes have been identified in the 1.5 map unit (m.u.)dpy-14-unc-29 region of chromosome I inCaenorhabditis elegans. Previous work defined nine genes with visible mutant phenotypes and nine genes with le...

    Kim S. McKim, Terence Starr, A. M. Rose in Molecular and General Genetics MGG (1992)