-
Article
A noncoding secret to stay young—protecting Treg cells to keep the balance in the liver
-
Article
Open AccessThe autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1
The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement, little is known about its molecular function in th...
-
Article
RNA: a double-edged sword in genome maintenance
All organisms must safeguard the integrity of their DNA to avoid deleterious consequences of genome instability, which have been linked to human diseases such as autoimmune disorders, neurodegenerative disease...
-
Article
RNA post-transcriptional modification speaks to chromatin
The role of N6-methyladenosine (m6A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m6A modification of nascent messenger RNA promotes transcription ...
-
Article
Open AccessPIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications
We develop PIRCh-seq, a method which enables a comprehensive survey of chromatin-associated RNAs in a histone modification-specific manner. We identify hundreds of chromatin-associated RNAs in several cell typ...
-
Article
An epitranscriptomic vulnerability in myeloid malignancies
A recent study finds that the N6-methyladenosine (m6A) modifier METTL3 regulates proliferation and differentiation in myeloid cells and acute myeloid leukemia (AML).
-
Article
m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
The authors assess the role of N6-methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating IL-7-mediated STAT5 activation.
-
Article
Erratum: Structural imprints in vivo decode RNA regulatory mechanisms
Nature 519, 486–490 (2015); doi: 10.1038/nature14263 In Fig. 2a of this Letter, an error in the placement of the labels on the pie chart was introduced during the production process. The correct numbers were r...
-
Article
Structural imprints in vivo decode RNA regulatory mechanisms
The single-stranded nature of RNAs synthesized in the cell gives them great scope to form different structures, but current methods to measure RNA structure in vivo are limited; now, a new methodology allows rese...
-
Protocol
Cloning Argonaute-Associated Small RNAs from Caenorhabditis elegans
Small RNA pathways fulfill a plethora of gene-regulatory functions in a variety of organisms. In the nematode worm, Caenorhabditis elegans, a number of endogenous small RNA pathways have been described, including...
