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Author Correction: Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates
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Open AccessThe autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1
The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement, little is known about its molecular function in th...
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Article
Open AccessInduction of synapse formation by de novo neurotransmitter synthesis
A vital question in neuroscience is how neurons align their postsynaptic structures with presynaptic release sites. Although synaptic adhesion proteins are known to contribute in this process, the role of neur...
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Article
Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes
The on-target pioneer factors Ascl1 and Myod1 are sequence-related but induce two developmentally unrelated lineages—that is, neuronal and muscle identities, respectively. It is unclear how these two basic hel...
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Generation of pure GABAergic neurons by transcription factor programming
Transient transcription factor expression rapidly induces a homogenous population of mature GABAergic neurons from human pluripotent stem cells, aiding the study of inhibitory neuron function and disease.
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Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates
The neuron-specific transcription factor Myt1l represses many somatic lineage programs, but not the neuronal lineage program, to both induce and maintain neuronal identity.
