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Article
Open AccessARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is thought to play a significant role both in tumor suppression and tumor initiation, which is highly dependent upon context. Previous studies hav...
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Article
ITGB4 is a prognostic biomarker and correlated with lung adenocarcinoma brain metastasis
The aim of this study is to explore the prognostic value and immune signature of ITGB4 expression in lung adenocarcinoma (LUAD) brain metastasis.
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Article
Teaching content recommendations in music appreciation courses via graph embedding learning
The traditional music appreciation course teaching model relies on questionnaires or manual decision-making to determine teaching content, which is time-consuming and easily reduces student satisfaction and te...
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Article
Non-negligible contribution of high-level volatile sulphur compounds to ozone photochemical formation in an industry zone in the North China Plain
The increasing amount of ozone (O3) pollution in China is attracting extensive scientific attention globally. This study presents direct evidence that high concentrations of volatile sulphur compounds (VSCs) acce...
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Article
Evaluating tide level under extreme rainfall in a large coastal basin
The design flood for a coastal basin based on model simulations can be impacted by various conditions other than design storm, such as tide level. However, the design storm and tide level are usually investiga...
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Article
Open AccessChromosome-level genome assembly of the Stoliczka’s Asian trident bat (Aselliscus stoliczkanus)
Stoliczka’s Asian trident bat (Aselliscus stoliczkanus) is a small-bodied species and very sensitive to climate change. Here, we presented a chromosome-level genome assembly of A. stoliczkanus by combining Illumi...
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Chapter and Conference Paper
A Diversified Multi-objective Particle Swarm Optimization Algorithm for Unsupervised Band Selection of Hyperspectral Images
Evolutionary algorithm (EA) with good search capability has been successfully extended to a mainstream band selection (BS) technique for hyperspectral images (HSIs). However, most of the existing methods still...
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Article
Spatio-temporal accuracy evaluation of MSWEP daily precipitation over the Huaihe River Basin, China: A comparison study with representative satellite- and reanalysis-based products
Multi-source weighted-ensemble precipitation (MSWEP) is one of the most popular merged global precipitation products with long-term spanning and high spatial resolution. While various studies have acknowledged...
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Article
Treadmill running alleviates adipose tissue browning and lipolysis in rats with heart failure
This study observed the effects of treadmill running on adipose tissue browning and lipolysis in rats with induced heart failure and elucidated the possible mechanism. Rats underwent abdominal aortic constrict...
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Article
Calculation of instream ecological water requirements under runoff variation conditions: Taking **tiaoxi River in Taihu Lake Basin as an example
Climate change and human activity can cause remarkable hydrological variation. Traits of hydrological series such as runoff before and after the change points could be significantly different, so the calculati...
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Chapter and Conference Paper
An Efficient Competitive Swarm Optimizer for Solving Large-Scale Multi-objective Optimization Problems
Recently, the large-scale optimization problems have become a common research topic in the field of evolutionary computation. It is hard to find optimal solutions when solving large-scale multi-objective optim...
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Article
Age-dependent association of CYP2C19 polymorphisms with clinical outcome of clopidogrel therapy in minor stroke patients with large-artery atherosclerosis
Previous studies on the association between CYP2C19 polymorphisms and therapeutic outcome of clopidogrel in stroke patients are inconclusive. We aimed to investigate the impact of CYP2C19 polymorphisms on ther...
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Article
Impact of diabetes mellitus simulations on bone cell behavior through in vitro models
Diabetes mellitus (DM) is related to impaired bone healing and an increased risk of bone fractures. While it is recognized that osteogenic differentiation and the function of osteoblasts are suppressed in DM, ...
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Chapter and Conference Paper
A Short Survey of Multi-objective Immune Algorithm Based on Clonal Selection
Multi-objective immune algorithm (MOIA) is a heuristic algorithm based on artificial immune system model. Due to its characteristics of antibody clonal selection and automatic antigen recognition in the immune...
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Article
Open AccessPIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications
We develop PIRCh-seq, a method which enables a comprehensive survey of chromatin-associated RNAs in a histone modification-specific manner. We identify hundreds of chromatin-associated RNAs in several cell typ...
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Article
Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment
Human embryonic stem cell (hESC) differentiation promises advances in regenerative medicine1–3, yet conversion of hESCs into transplantable cells or tissues remains poorly understood. Using our keratinocyte diffe...
