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Article
Unraveling Estrogen and PCSK9’s Roles in Lipid Metabolism Disorders among Ovariectomized Mice
We explore the interaction between estrogen and PCSK9 and their collective impact on lipid metabolism, especially concerning the regulation of low-density lipoprotein receptor levels. Utilizing both animal and...
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Article
Open AccessA lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis
Inflammatory bowel diseases (IBD) are known to have complex, genetically influenced etiologies, involving dysfunctional interactions between the intestinal immune system and the microbiome. Here, we characteri...
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Article
Open AccessRNA m6A modification and its function in diseases
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers...
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Article
m6A mRNA methylation sustains Treg suppressive functions
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Article
m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
The authors assess the role of N6-methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating IL-7-mediated STAT5 activation.
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Article
Open AccessLong-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice
Epidemiological data provide strong evidence of dramatically increasing incidences of many autoimmune diseases in the past few decades, mainly in western and westernized countries. Recent studies clearly revea...
