22 Result(s)

Article

Inverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age

Genome-wide-association studies have identified numerous body mass index (BMI)-associated variants, but it is unclear how these relate to weight gain in adults at different ages.

G Rukh, S Ahmad, U Ericson, G Hindy, T Stocks… in International Journal of Obesity (2016)

Article

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

To date, the molecular function of most of the reported type 2 diabetes-associated loci remains unknown. The introduction or removal of cytosine–phosphate–guanine (CpG) dinucleotides, which are possible sites ...

T. A. Dayeh, A. H. Olsson, P. Volkov, P. Almgren, T. Rönn, C. Ling in Diabetologia (2013)

Article

A common variant upstream of the PAX6 gene influences islet function in man

Impaired glucose tolerance and impaired insulin secretion have been reported in families with PAX6 mutations and it is suggested that they result from defective proinsulin processing due to lack of prohormone con...

E. Ahlqvist, F. Turrini, S. T. Lang, J. Taneera, Y. Zhou, P. Almgren… in Diabetologia (2012)

Article

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.

P. Almgren, M. Lehtovirta, B. Isomaa, L. Sarelin, M. R. Taskinen… in Diabetologia (2011)

Article

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study

We studied the impact of a family history of type 2 diabetes on physical fitness, lifestyle factors and diabetes-related metabolic factors.

B. Isomaa, B. Forsén, K. Lahti, N. Holmström, J. Wadén, O. Matintupa… in Diabetologia (2010)

Article

Prediction of postpartum diabetes in women with gestational diabetes mellitus

We studied the incidence of postpartum diabetes after gestational diabetes mellitus and investigated biochemical and clinical predictors of postpartum diabetes.

M. Ekelund, N. Shaat, P. Almgren, L. Groop, K. Berntorp in Diabetologia (2010)

Article

4.2 Chromosome 2q12: the Adrenergic Receptor 2b (ADRA2b) Gene and Metabolic Syndrome in Swedish — is there a Link?

C. Fava, M. Montagnana, P. Almgren, P. Burri… in High Blood Pressure & Cardiovascular Preve… (2008)

Article

4.3 The V433M Variant of the CYP4F2 is Associated with Ischemic Stroke in Male Swedish Beyond its Effect on Blood Pressure

C. Fava, M. Montagnana, P. Almgren, P. Minuz… in High Blood Pressure & Cardiovascular Preve… (2008)

Article

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle

Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXP...

T. Rönn, P. Poulsen, O. Hansson, J. Holmkvist, P. Almgren, P. Nilsson… in Diabetologia (2008)

Article

Polymorphisms in the gene encoding the voltage-dependent Ca²⁺ channel Ca_V2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion

Glucose-stimulated insulin secretion is dependent on the electrical activity of beta cells; hence, genes encoding beta cell ion channels are potential candidate genes for type 2 diabetes. The gene encoding the...

J. Holmkvist, D. Tojjar, P. Almgren, V. Lyssenko, C. M. Lindgren, B. Isomaa… in Diabetologia (2007)

Article

Impact of the peroxisome proliferator activated receptor-γ coactivator-1β (PGC-1β) Ala203Pro polymorphism on in vivo metabolism, PGC-1β expression and fibre type composition in human skeletal muscle

Peroxisome proliferator activated receptor-γ coactivator-1β (PGC-1β, also known as PPARGC1B) expression is reduced in skeletal muscle from patients with type 2 diabetes mellitus and in elderly subjects. Ala203Pro...

C. Ling, L. Wegner, G. Andersen, P. Almgren, T. Hansen, O. Pedersen… in Diabetologia (2007)

Article

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes

Activation of the insulin receptor substrate-1 (IRS1) is a key initial step in the insulin signalling pathway. Despite several reports of association of the G972R polymorphism in its gene IRS1 with type 2 diabete...

J. C. Florez, M. Sjögren, C. M. Agapakis, N. P. Burtt, P. Almgren… in Diabetologia (2007)

Article

Common variants in HNF-1 α and risk of type 2 diabetes

Mutations in the hepatocyte nuclear factor 1-α gene (HNF-1α, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in...

J. Holmkvist, C. Cervin, V. Lyssenko, W. Winckler, D. Anevski, C. Cilio… in Diabetologia (2006)

Article

Common variants in MODY genes increase the risk of gestational diabetes mellitus

N. Shaat, E. Karlsson, Å. Lernmark, S. Ivarsson, K. Lynch, H. Parikh… in Diabetologia (2006)

Article

Common variants in MODY genes increase the risk of gestational diabetes mellitus

Impaired beta cell function is the hallmark of gestational diabetes mellitus (GDM) and MODY. In addition, women with MODY gene mutations often present with GDM, but it is not known whether common variants in M...

N. Shaat, E. Karlsson, Å. Lernmark, S. Ivarsson, K. Lynch, H. Parikh… in Diabetologia (2006)

Article

Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus

Gestational diabetes mellitus (GDM) and type 2 diabetes share a common pathophysiological background, including beta cell dysfunction and insulin resistance. In addition, women with GDM are at increased risk o...

N. Shaat, M. Ekelund, Å. Lernmark, S. Ivarsson, P. Almgren, K. Berntorp… in Diabetologia (2005)

Article

Diabetes-associated HLA genotypes affect birthweight in the general population

The aim of our study was to test the hypothesis that HLA genotypes conferring risk of diabetes, cord blood autoantibodies, or both are associated with increased birthweight.

H. E. Larsson, K. Lynch, B. Lernmark, A. Nilsson, G. Hansson, P. Almgren… in Diabetologia (2005)

Article

40^th EASD Annual Meeting of the European Association for the Study of Diabetes

M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)