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Article
Irradiance, Water Column O2, and Tide Drive Internal O2 Dynamics and Meristem H2S Detection in the Dominant Caribbean-Tropical Atlantic Seagrass, Thalassia testudinum
Water column hypoxia, low partial pressure of oxygen (pO2), and hydrogen sulfide (H2S) intrusion, a phytotoxin, are factors linked to global seagrass decline. While many lab experiments have examined these relati...
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Article
Association studies of genetic scores of serum vitamin B12 and folate levels with symptoms of depression and anxiety in two danish population studies
Observational studies have suggested low serum levels of vitamin B12 or folate to be risk factors of depression and anxiety. However, these results may be biased by confounding and reverse causation. Mendelian...
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Article
Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies
The aim was to examine the association of genetic risk scores (GRSs) of vitamin B12 and folate-associated variants with blood pressure and lipids.
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Article
Prenatal exposure to systemic antibacterials and overweight and obesity in Danish schoolchildren: a prevalence study
Prenatal exposure to antibacterials may permanently dysregulate fetal metabolic patterns via epigenetic pathways or by altering maternal microbiota. We examined the association of prenatal exposure to systemic...
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Article
Open AccessSpecific gut microbiota features and metabolic markers in postmenopausal women with obesity
Gut microbial gene richness and specific bacterial species are associated with metabolic risk markers in humans, but the impact of host physiology and dietary habits on the link between the gut microbiota and ...
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Article
Open AccessTreatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss
Recent studies indicate that glucagon-like peptide (GLP)-1 inhibits appetite in part through regulation of soluble leptin receptors. Thus, during weight loss maintenance, GLP-1 receptor agonist (GLP-1RA) admin...
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Article
Open Access3.3: Associations Between Plasma Incretin Hormone Release and Aortic Stiffness and Blood Pressure in Individuals Without Known Diabetes: The Addition-Pro Study
The role of incretin hormone release on vascular structure and function remains unclear. Hence, in 836 Danish individuals without know diabetes and without antihypertensive treatment, we examined the associati...
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Article
Open AccessEHMTI-0380. The association of migraine susceptibility loci with severe migraine characteristics in a clinic-based migraine sample
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Article
Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes
MODY is believed to be caused by at least 13 different genes. Five rare mutations at the BLK locus, including only one non-synonymous p.A71T variant, were reported to segregate with diabetes in three MODY familie...
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Article
Open AccessExome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with...
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Article
The frequent UCP2 −866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes
Uncoupling protein 2 (UCP2) is involved in regulating ATP synthesis, generation of reactive oxygen species and glucose-stimulated insulin secretion in β-cells. Polymorphisms in UCP2 may be associated with obesity...
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Article
Open AccessBeyond the fourth wave of genome-wide obesity association studies
Obesity and related complications are major health burdens. Almost 700 million adults are currently obese globally and the prevalence is predicted to rise towards 2030. The sudden change of lifestyle with phys...
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Article
Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits
Heritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimula...
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Article
Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes
There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common ...
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Article
Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals
Genome-wide association studies have identified novel WHR and BMI susceptibility loci. The aim of this study was to elucidate if any of these loci had an effect on quantitative measures of glucose homeostasis,...
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Article
A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
An accurate molecular diagnosis of diabetes subtype confers clinical benefits; however, many individuals with monogenic diabetes remain undiagnosed. Biomarkers could help to prioritise patients for genetic inv...
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Article
Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1
The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/...
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Article
Erratum to: Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release
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Article
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release
By combining multiple genome-wide association (GWA) studies and comprehensive replication efforts, 12 novel type 2 diabetes associated loci have recently been discovered. Here we evaluate the effect of lead va...
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Article
The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals
A genome-wide association study in the Japanese population reported two genome-wide significant loci associated with type 2 diabetes of which the VPS13C/C2CD4A/C2CD4B locus was replicated in Europeans. We looked ...
