59 Result(s)
within
P Wesseling
English
-
Article
Open AccessUltra-fast deep-learned CNS tumour classification during surgery
Central nervous system tumours represent one of the most lethal cancer types, particularly among children1. Primary treatment includes neurosurgical resection of the tumour, in which a delicate balance must be st...
-
Article
Open AccessMedulloblastoma in adults: evaluation of the Dutch society for neuro-oncology treatment protocol
Medulloblastoma is a rare tumor in adults. The objective of this nationwide, multicenter study was to evaluate the toxicity and efficacy of the Dutch treatment protocol for adult medulloblastoma patients.
-
Article
Open AccessNTRK rearrangements in a subset of NF1-related malignant peripheral nerve sheath tumors as novel actionable target
-
Article
Open AccessNon-invasively measured brain activity and radiological progression in diffuse glioma
Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between bra...
-
Article
Contribution of CSF cytology in the diagnostic work-up of breast cancer patients with neurological symptoms: a retrospective analysis over two decades
The aim of this study was to evaluate the contribution of cytological analysis of cerebrospinal fluid (CSF) in the diagnostic work-up of breast cancer patients who present with neurological symptoms suspected ...
-
Chapter
Computing Interfaces in Diverse Applications
Mathematical models and computing methods for problems involving moving interfaces are considered. These occur in a great variety of applications, and mathematical models provide a unifying framework, facilita...
-
Article
Open AccessComputing three-dimensional two-phase flows with a mass-conserving level set method
A method is described to compute three- dimensional two-phase flow, allowing large density ratios and coalescence and break-up of bubbles. The level set method is used to describe interfaces, and the volume-of...
-
Article
Effects of Annealing and Pressure on Devitrification and Mechanical Properties of Amorphous Al87Ni7Gd6
Annealing studies at different temperatures, as well as those conducted with 940 MPa hydrostatic pressure, were conducted on amorphous ribbons of Al87Ni7Gd6. The studies were performed to investigate the evolutio...
-
Article
Open AccessSecondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chem...
-
Article
Open AccessCharacterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI
To enhance the success rate of antiangiogenic therapies in the clinic, it is crucial to identify parameters for tumour angiogenesis that can predict response to these therapies. In brain tumours, one such para...
-
Article
Open AccessLong-term survival and transmission of INI1-mutation via nonpenetrant males in a family with rhabdoid tumour predisposition syndrome
Rhabdoid tumour predisposition syndrome (RTPS) is a rare syndrome caused by inheritance of a mutated INI1 gene for which only two multigeneration families have been reported. To further characterise the genotype ...
-
Article
Micronodular transformation as a novel mechanism of VEGF-A-induced metastasis
How and why tumors metastasize is still a matter of debate. The assumption is that mutations render tumor cells with a metastatic phenotype, enabling entrance in and transport through lymph or blood vessels. D...
-
Article
Giant cavernous hemangiomas: report of three cases
Giant cavernous hemangiomas occur very rarely, and little has been reported about their behavior. In this case report three cavernous hemangiomas with a diametric measure between 6 cm and 7 cm and distinct fea...
-
Article
A patient with recurrent hypercortisolism after removal of an ACTH-secreting pituitary adenoma due to an adrenal macronodule
A 41-yr-old female was referred for signs and symptoms of Cushing’s syndrome. Cortisol was not suppressed by 1 mg dexamethasone (0.41 μmol/l). Midnight cortisol and ACTH were 0.44 μmol/l and 18 pmol/l, respect...
-
Article
Three-dimensional reconstruction of tumor microvasculature: Simultaneous visualization of multiple components in paraffin-embedded tissue
Three-dimensional (3D) visualization of microscopic structures may provide useful information about the exact 3D configuration, and offers a useful tool to examine the spatial relationship between different co...
-
Article
Development and malformations of the human pyramidal tract
The corticospinal tract develops over a rather long period of time, during which malformations involving this main central motor pathway may occur. In rodents, the spinal outgrowth of the corticospinal tract o...
-
Article
Inverse Correlation between Genetic Aberrations and Malignancy Grade in Ependymal Tumors: A Paradox?
Objective: The goal of our study was to investigate the inverse correlation between number of genetic aberrations and malignancy grade in ependymal tumors at the ploidy level.
-
Article
Development and developmental disorders of the human cerebellum
The human cerebellum develops over a long time, extending from the early embryonic period until the first postnatal years. This protracted development makes the cerebellum vulnerable to a broad spectrum of dev...
-
Article
Strength differential measurements in IN 718: Effects of superimposed pressure
-
Chapter and Conference Paper
An unstructured staggered scheme for the Navier—Stokes equations
A novel scheme for viscous incompressible flows on unstructured grids is introduced. A staggered positioning of the variables is used: the pressure is located in the centroids of the triangles while the normal...
