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Article
Open AccessMolecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study
To test the prognostic value of tumour protein and genetic markers in colorectal cancer (CRC) and examine whether deficient mismatch repair (dMMR) tumours had a distinct profile relative to proficient mismatch...
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Article
Lymph road map** obtained via blue sentinel node detection to avoid middle colic artery resection for highly selected colon cancer cases: proof of a concept?
In theory, perioperative detection of lymph nodes with the injection of isosulfan blue dye should provide lymph road map** (LRM) able to direct the resection. However, there is no supporting evidence for thi...
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Article
Open AccessCarcinoma of the colon
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Article
Open AccessCancer of the rectum
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Article
Open AccessExtensive molecular screening for hereditary non-polyposis colorectal cancer
The genetic abnormalities underlying hereditary non-polyposis colorectal cancer (HNPCC) are germline mutations in one of five DNA mismatch repair genes or in the TGFβRII gene. The aim of our study was to evaluate...
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Article
Open AccessTreatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin
The purpose of this study was to evaluate by a retrospective analysis of 53 patients the efficacy of chemotherapy combining etoposide and cisplatin in the treatment of neuroendocrine tumours. The regimen was a...
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Article
Absence of somatic alterations of the EB1 gene adenomatous polyposis coli-associated protein in human sporadic colorectal cancers
The human EB1 gene product was recently found, by a yeast two-hybrid screening, to be associated with the carboxy terminus of the APC (adenomatous polyposis coli) protein, the product of a tumour-suppressor ge...
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Article
Circumferential pharyngolaryngectomy with total esophagectomy for locally advanced carcinomas
Background: Forty-nine cases of circumferential pharyngolaryngectomy with total esophagectomy (PLTE) done between 1982 and 1996 were studied retrospectively. These procedures were performed for advanced squamous...
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Complications of Total Abdominal and Spleen Irradiation in Patients With Lymphomas
Exploratory laparotomy has shown that, in patients with non-Hodgkin’s lymphomas, involvement of para-aortic nodes is associated with positive mesenteric nodes in 80% of well- differentiated nodular or diffuse ...
