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Open AccessPancreatic adenocarcinoma third line systemic treatments: a retrospective cohort study
Chemotherapy for metastatic pancreatic adenocarcinoma (PDAC) primarily relies on FOLFIRINOX (LV5FU- irinotecan – Oxaliplatine) and Gemcitabine – Nab-Paclitaxel in the first-line setting. However, second-lines ...
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Article
The Frequency of Germline BRCA and Non-BRCA HR-Gene-Variants in a Cohort of Pancreatic Cancer Patients
Germline DNA alterations affecting homologous recombination pathway genes have been associated with pancreatic cancer (PC) risk. BRCA2 is the most studied gene and affects the management of PC patients and the...
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Article
Is intra-arterial hepatic chemotherapy painful?
Liver metastases are mainly supplied by the hepatic artery, allowing the administration of intra-arterial hepatic chemotherapy (IAHC) while preserving normal parenchyma. The progression-free survival and respo...
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Article
Open AccessDesign of fiber-integrated tunable thermo-optic C-band filter based on coated silicon slab
Optical filters are required to have narrow band-pass filtering in the spectral C-band for applications such as signal tracking, sub-band filtering or noise suppression. These requirements lead to a variety of...
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Article
Hommage à Franck Bonnetain
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Article
Chirurgie à visée curative des métastases péritonéales
L’exérèse complète des métastases péritonéales (MP), suivie de chimiohyperthermie intrapéritonéale (CHIP, dont l’impact thérapeutique précis n’est pas encore connu), permet d’obtenir de nombreuses guérisons ch...
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Article
Chimiothérapie des métastases d’origine colorectale jamais résécables : stratégie multiligne, thérapies ciblées
Le développement d’anticancéreux plus actifs (oxaliplatine, irinotécan) associés aux thérapies ciblées ainsi que les avancées de la chirurgie ont allongé la survie des patients atteints de cancer colorectal mé...
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Article
Open AccessSmall bowel adenocarcinoma phenoty**, a clinicobiological prognostic study
Small bowel adenocarcinoma (SBA) is a rare tumour with a poor prognosis. Molecular biology data on SBA carcinogenesis are lacking.
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Article
Caractérisation des tumeurs neuroendocrines digestives ou thoraciques
Once the diagnosis of a neuroendocrine tumour has been made, characterisation is an essential step before therapy. It comes before the decision regarding treatment is made. This requires a multidisciplinary te...
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Article
Open AccessTumour-infiltrating CD68+ and CD57+ cells predict patient outcome in stage II–III colorectal cancer
The aim of our study was to evaluate the prognostic role of immunological microenvironnement in stage II–III CRC patients.
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Article
Intra-Arterial Hepatic Chemotherapy: A Comparison of Percutaneous Versus Surgical Implantation of Port-Catheters
To compare retrospectively the safety and efficacy of percutaneous and surgical implantations of port-catheters for intra-arterial hepatic chemotherapy (IAHC).
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Article
Chimiothérapie systémique des cancers avancés des voies biliaires: actualités et perspectives
Biliary tract cancers, with fewer than 2,000 new cases per year in France, must be regarded as orphan tumors. There is currently no evidence of the benefit of neoadjuvant or adjuvant chemotherapy and/or radiot...
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Article
Lymph road map** obtained via blue sentinel node detection to avoid middle colic artery resection for highly selected colon cancer cases: proof of a concept?
In theory, perioperative detection of lymph nodes with the injection of isosulfan blue dye should provide lymph road map** (LRM) able to direct the resection. However, there is no supporting evidence for thi...
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Le traitement médical des cancers colorectaux métastatiques en 2009: quels traitements pour quels patients?
Connaître les autorisations de mise sur le marché (AMM) des différents agents pharmacologiques;
Quelles stratégies pour q...
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Article
Nouveautés dans la chimiothérapie du cancer colorectal métastasé
La chimiothérapie des cancers colorectaux a été profondément modifiée ces dernières années. Alors même que la place respective de l’irinotécan et de l’oxaliplatine n’était pas complètement définie, les thérapi...
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Tumeurs endocrines gastro-entéro-pancréatiques (TE GEP): facteurs pronostiques
Ce chapitre fait le point sur les facteurs pronostiques des tumeurs endocrines gastro-entéro-pancréatiques (TE GEP) non à petites cellules (1, 2). Nous utiliserons le terme de « tumeur endocrine », pour définir d...
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Cancer du pancréas exocrine
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Article
Application clinique de la TEP dans la prise en charge du cancer colorectal
La tomographie par émission de positons ou TEP est le premier examen d’imagerie fonctionnelle disponible en cancérologie. Dans le domaine du cancer colorectal, la TEP a très rapidement occupé une place de choi...
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Article
Establishment of regional differences in brush border enzymatic activities during the development of fetal mouse small intestine
In order to study the establishment of regional differences in brush border enzymic activities during the development of fetal mouse small intestine we have followed (1) the differentiation of microvilli by mo...
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Article
Effect of clofibrate on the small intestine of fetal mice
Pregnant Swiss ICR mice were injected with clofibrate at different dosages and time intervals, and embryos were removed either at 17 or 18 days of gestation. In embryos sacrificed at 17 days the level of intes...