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Article
ATM activity in T cells is critical for immune surveillance of lymphoma in vivo
The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer pre...
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Article
Host microbiota constantly control maturation and function of microglia in the CNS
In this study, the authors show that host microbiota play a key role in modulating microglia homeostasis. Germ-free mice or mice with only limited microbiota complexity displayed defects in microglial cell pro...
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Article
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance
In Caenorhabditis elegans, genome instability in the form of exogenous and endogenous DNA damage in germ cells evokes elevated heat- and oxidative-stress resistance in somatic tissues; this is mediated by MPK-1, ...
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Article
Open AccessTherapeutic concentrations of antibiotics inhibit Shiga toxin release from enterohemorrhagic E. coli O104:H4 from the 2011 German outbreak
The shiga toxin-producing E. coli (STEC) O104:H4 caused a major outbreak in Germany in spring 2011. STEC are usually susceptible to common antibiotics. However, antibiotic treatment of STEC-infected patients is n...
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Article
Dual role of B cells with accelerated onset but reduced disease activity in P0106–125-induced experimental autoimmune neuritis of IgH0/0 mice
The role of B cells in autoimmune-mediated diseases of the peripheral nervous system was studied in experimental autoimmune neuritis (EAN) in B cell deficient IgH0/0 C57BL/6J mice having been immunized with P0106...
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Article
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
Riboflavin kinase has been identified as a novel interacting partner for the death domain of receptor-1 for tumour necrosis factor (TNF-R1). It is required to recruit to and functionally couple p22phox to TNF-R1....
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Article
Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes
Granules containing perforin and granzymes are secreted from cytotoxic T lymphocytes. Krönke and co-workers find that acid sphingomyelase is needed for granule shrinkage just before exocytosis in this process.
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Article
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
The function of the adaptor protein TRADD is uncertain. Teams led by Pasparakis and Liu solidify TRADD's function in TNF receptor signaling and extend its influence to TRIF-dependent Toll-like receptor pathways.
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Article
Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice
In this report we analyzed the impact of interleukin-4 (IL-4) on tumor-associated simian virus 40 (SV40) large T-antigen (TAg)-specific CD8+ cytotoxic T cells during rejection of syngeneic SV40 transformed mKSA t...
