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Article
Open AccessTreatment with Upadacitinib in Active Psoriatic Arthritis: Efficacy and Safety Data of the First 192 Patients from the UPJOINT Study, a Multicentre, Observational Study in Clinical Practice
Our aim was to investigate the efficacy and safety of upadacitinib (UPA) in patients with either oligo- or polyarticular active psoriatic arthritis (PsA) using routine clinical practice data from an observatio...
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Article
Loss of type I IFN responsiveness impairs natural killer cell antitumor activity in breast cancer
Competent type I IFN signaling is the lynchpin of most immune surveillance mechanisms and has recently proven critical to the efficacy of several anticancer agents. Expression of the type I IFN receptor, IFNAR...
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Article
Open AccessOral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be bioavailable in various organs, and in-turn exert phenotypic changes is highly ...
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Article
Open AccessSTAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These i...
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Article
Erratum: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells
Nat. Immunol. 13, 1171–1177 (2012); published online 11 November 2012; corrected after print 19 November 2012 In the version of this article initially published, two designations for major histocompatibility c...
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Article
Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells
NK cell licensing is governed by the interaction of Ly49 receptors with peptide-MHC complexes. Smyth and colleagues show that the nonclassical MHC class I molecule H2-M3 can also license NK cell functional dev...
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Article
Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice
In this report we analyzed the impact of interleukin-4 (IL-4) on tumor-associated simian virus 40 (SV40) large T-antigen (TAg)-specific CD8+ cytotoxic T cells during rejection of syngeneic SV40 transformed mKSA t...
