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Article
An unusual case of a highly progressive supratentorial capillary haemangioblastoma – histopathological considerations
We describe a case of a rapidly progressive, sporadic, non-von Hippel-Lindau (VHL) disease associated supratentorial capillary haemangioblastoma. Despite the classical histopathological presentation consisting...
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Article
Differential effects of prolonged isoflurane anesthesia on plasma, extracellular, and CSF glutamate, neuronal activity, 125I-Mk801 NMDA receptor binding, and brain edema in traumatic brain-injured rats
Background. Volatile anesthetics reduce neuronal excitation and cerebral metabolism but can also increase intracellular water accumulation in normal and injured brains. While attenuation of neuronal excitation an...
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Chapter and Conference Paper
Detection of Secondary Insults by Brain Tissue pO2 and Bedside Microdialysis in Severe Head Injury
We evaluated bedside cerebral on-line microdialysis for early detection of cerebral hypoxia in patients with traumatic brain injury. 24 severely head injured patients (Glasgow Coma Score ≤ 8) were studied. Pat...
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Chapter and Conference Paper
Norepinephrine is Superior to Dopamine in Increasing Cortical Perfusion Following Controlled Cortical Impact Injury in Rats
Following traumatic brain injury catecholamines are routinely applied to increase cerebral perfusion. To date, it remains controversial if infusion of catecholamines is associated with diminished cerebral perf...
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Chapter and Conference Paper
Neuronal Activity Determined by Quantitative EEG and Cortical Microdialysis is Increased Following Controlled Cortical Impact Injury in Rats
Following brain injury increased glutamate release is linked to sustained neuronal activation resulting in excitotoxic tissue damage. Isoflurane anesthesia has been shown to decrease electroencephalo-graphic (...
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Chapter and Conference Paper
Time Course of Various Interstitial Metabolites Following Subarachnoid Hemorrhage Studied by on-Line Microdialysis
Subarachnoid hemorrhage (SAH) is one of the most devastating of all cerebrovascular disorders [10]. One of the most serious complications of SAH remains vasospasm [3, 9]. Bedside cerebral microdialysis is a recen...