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  1. No Access

    Article

    Prophylactic effects of cucurbitacin B in the EAE Model of multiple sclerosis by adjustment of STAT3/IL-23/IL-17 axis and improvement of neuropsychological symptoms

    Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. Although remarkable progress has been made in treating MS, current therapies are less effective in protecting against t...

    Samaneh Reiszadeh-Jahromi, Mohammad Haddadi, Pegah Mousavi… in Metabolic Brain Disease (2022)

  2. No Access

    Article

    Alpha‐lipoic acid ameliorates tauopathy‐induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor

    Tauopathies belong to a heterogeneous class of neuronal diseases resulting in the metabolic disturbance. A disulfide natural compound of Alpha-Lipoic acid (ALA) has shown numerous pharmacologic, antioxidant, a...

    Elahe Zarini-Gakiye, Nima Sanadgol, Kazem Parivar… in Metabolic Brain Disease (2021)

  3. No Access

    Article

    Sepantronium Bromide (YM155), A Small Molecule Survivin Inhibitor, Promotes Apoptosis by Induction of Oxidative Stress, Worsens the Behavioral Deficits and Develops an Early Model of Toxic Demyelination: In Vivo and In-Silico Study

    Cuprizone (cup) model targets oligodendrocytes (OLGs) degeneration and is frequently used for the mechanistic understanding of de- and remyelination. Improperly, this classic model is time-consuming and the ex...

    Samaneh Reiszadeh-Jahromi, Mohammad-Reza Sepand… in Neurochemical Research (2019)

  4. No Access

    Article

    Ameliorative effects of hydrogen sulfide (NaHS) on chronic kidney disease-induced brain dysfunction in rats: implication on role of nitric oxide (NO) signaling

    Chronic kidney disease (CKD) is a major public health problem worldwide and is associated with spatial learning deficits. The aim of the present study was to evaluate the protective effects of hydrogen sulfide...

    Hassan Askari, Mohammad Foad Abazari, Pegah Ghoraeian… in Metabolic Brain Disease (2018)

  5. No Access

    Article

    Evaluation of metformin effects in the chronic phase of spontaneous seizures in pilocarpine model of temporal lobe epilepsy

    Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy that sometimes responds to dietary manipulation such as the ‘ketogenic diet’. Here we have investigated the effects of metformin in the ...

    Soraya Mehrabi, Nima Sanadgol, Mahmood Barati, Ali Shahbazi… in Metabolic Brain Disease (2018)

  6. No Access

    Article

    Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation

    Multiple Sclerosis (MS), is a disease that degenerates myelin in central nervous system (CNS). Reactive oxygen species (ROSs) are toxic metabolites, and accumulating data indicate that ROSs-mediated apoptosis ...

    Nima Sanadgol, Fereshteh Golab, Hassan Askari, Fatemeh Moradi… in Metabolic Brain Disease (2018)