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  1. No Access

    Article

    Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis

    Necroptosis is a regulated cell death that is governed by mixed lineage kinase domain-like, receptor-interacting serine-threonine kinase 3 and commonly displays with necrosis morphological characteristics. Thi...

    Mohammad-Reza Sepand, Mehdi Aliomrani… in Environmental Science and Pollution Resear… (2020)

  2. No Access

    Article

    Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats

    The clinical application of methotrexate (MTX), an efficacious cytotoxic drug, is restricted due to its associated liver toxicity. Ellagic acid (EA), a natural polyphenol, possesses hepatoprotective, antioxida...

    Reihaneh Ebrahimi, Mohammad Reza Sepand… in DARU Journal of Pharmaceutical Sciences (2019)

  3. No Access

    Article

    Sepantronium Bromide (YM155), A Small Molecule Survivin Inhibitor, Promotes Apoptosis by Induction of Oxidative Stress, Worsens the Behavioral Deficits and Develops an Early Model of Toxic Demyelination: In Vivo and In-Silico Study

    Cuprizone (cup) model targets oligodendrocytes (OLGs) degeneration and is frequently used for the mechanistic understanding of de- and remyelination. Improperly, this classic model is time-consuming and the ex...

    Samaneh Reiszadeh-Jahromi, Mohammad-Reza Sepand… in Neurochemical Research (2019)

  4. No Access

    Article

    Sumatriptan protects against myocardial ischaemia–reperfusion injury by inhibition of inflammation in rat model

    Ischemic heart disease is a leading cause of death on a global scale, placing major socio-economic burdens on health systems worldwide. Myocardial ischaemia and reperfusion (I/R)-induced tissue injury is assoc...

    Mohammad Sheibani, Hedyeh Faghir-Ghanesefat, Saman Dehpour… in Inflammopharmacology (2019)

  5. No Access

    Article

    Acetyl-l-Carnitine Attenuates Arsenic-Induced Oxidative Stress and Hippocampal Mitochondrial Dysfunction

    Augmentation of mitochondrial oxidative stress through activating a series of deadly events has implicated as the main culprit of arsenic toxicity and therapeutic approaches based on improving mitochondrial fu...

    Hedieh Keshavarz-Bahaghighat, Mohammad Reza Sepand… in Biological Trace Element Research (2018)

  6. Article

    Open Access

    Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis

    Sepsis is a debilitating systemic disease and described as a severe and irregular systemic inflammatory reaction syndrome (SIRS) against infection. We employed CLP (Cecal Ligation and Puncture) model in rats t...

    Mehdi Aliomrani, Mohammad Reza Sepand… in DARU Journal of Pharmaceutical Sciences (2016)

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  7. No Access

    Article

    Effect of Acetyl-l-Carnitine on Antioxidant Status, Lipid Peroxidation, and Oxidative Damage of Arsenic in Rat

    Arsenic (As) is a widespread environmental contaminant present around the world in both organic and inorganic forms. Oxidative stress is postulated as the main mechanism for As-induced toxicity. This study was...

    Mohammad Reza Sepand, Kamal Razavi-Azarkhiavi… in Biological Trace Element Research (2016)

  8. No Access

    Article

    Satureja bachtiarica ameliorate beta-amyloid induced memory impairment, oxidative stress and cholinergic deficit in animal model of Alzheimer’s disease

    Extracellular deposition of Beta-amyloid peptide (Aβ) is the main finding in the pathophysiology of Alzheimer’s disease (AD), which damages cholinergic neurons through oxidative stress and reduces the choliner...

    Maliheh Soodi, Soodabeh Saeidnia, Mohammad Sharifzadeh… in Metabolic Brain Disease (2016)