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Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines

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  1. Article

    Open Access

    Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the down...

    Sireesha V Garimella, Kristie Gehlhaus, Jennifer L Dine… in Breast Cancer Research (2014)

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  2. Article

    Open Access

    Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer

    Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is diagnosed in approximately 15% of all human breast cancer (BrCa) patients. Currently, no targeted therapies exist for this...

    Christina N Bennett, Christine C Tomlinson… in Breast Cancer Research (2012)

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  3. Article

    Open Access

    Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells

    Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC cells ca...

    Amanda B Hummon, Jason J Pitt, Jordi Camps, Georg Emons, Susan B Skube… in Molecular Cancer (2012)

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  4. Article

    Open Access

    SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies

    Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant challenges for contemporary biological assays....

    Michael C Ryan, Barry R Zeeberg, Natasha J Caplen, James A Cleland… in BMC Bioinformatics (2008)

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  5. Article

    Open Access

    Pvt1-encoded microRNAs in oncogenesis

    The functional significance of the Pvt1 locus in the oncogenesis of Burkitt's lymphoma and plasmacytomas has remained a puzzle. In these tumors, Pvt1 is the site of reciprocal translocations to immunoglobulin loc...

    Gabriele B Beck-Engeser, Amy M Lum, Konrad Huppi, Natasha J Caplen… in Retrovirology (2008)

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  6. Article

    Open Access

    Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo

    The cationic lipid Genzyme lipid (GL) 67 is the current "gold-standard" for in vivo lung gene transfer. Here, we assessed, if GL67 mediated uptake of siRNAs and asODNs into airway epithelium in vivo.

    Uta Griesenbach, Chris Kitson, Escudero Sara Garcia, Raymond Farley… in Respiratory Research (2006)

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  7. Article

    Book reviews

    An Introduction to Recombinant DNA in Medicine (2nd edn).

    Natasha J Caplen in Heredity (1997)

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