30 Result(s)
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Naihe **g
Cell Biology
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Article
Open AccessContinuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains
Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantation in host brains under continuous immunosuppressive admin...
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Open AccessGeneration of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells
Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI). These disorders are current...
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Open AccessThe therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder associated with aging. Due to its insidious onset, protracted progression, and unclear pathogenesis, it is considered one of the most obs...
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Open AccessAuthor Correction: Formative pluripotent stem cells show features of epiblast cells poised for gastrulation
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Open AccessFormative pluripotent stem cells show features of epiblast cells poised for gastrulation
The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively. However, these two states of pluripotenc...
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Mitochondrial replacement in macaque monkey offspring by first polar body transfer
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Open AccessAccelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies
Social hierarchies emerged during evolution, and social rank influences behavior and health of individuals. However, the evolutionary mechanisms of social hierarchy are still unknown in amniotes. Here we devel...
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Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development
Primary germ layers have the potential to form all tissues in the mature organism, and their formation during gastrulation requires precise epigenetic modulation of both proximal and distal regulatory elements...
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Open AccessRegulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14
RNA-binding proteins with intrinsically disordered regions (IDRs) such as Rbm14 can phase separate in vitro. To what extent the phase separation contributes to their physiological functions is however unclear....
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Author Correction: Hormones induce the formation of luminal-derived basal cells in the mammary gland
In the initial published version of this article, there was a mistake in one author name (**gsong Li). The correct name should be “**song Li”. This correction does not affect the description of the results o...
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Hormones induce the formation of luminal-derived basal cells in the mammary gland
In the mammary gland, it is widely believed that the luminal cells are unipotent after birth, contributing only to the luminal compartment in normal development. Here, by lineage tracing, we uncovered an unexp...
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Author Correction: Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation
In the version of this Article originally published, the first name of author Guangdun Peng was spelled incorrectly as Guangdum. This has now been amended in all versions of the Article.
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Article
Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation
The morphogenetic remodelling of embryo architecture after implantation culminates in pro-amniotic cavity formation. Despite its key importance, how this transformation occurs remains unknown. Here, we apply h...
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Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
In the version of this Technical Report originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions...
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Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
Embryonic stem cells can be incorporated into the develo** embryo and its germ line, but, when cultured alone, their ability to generate embryonic structures is restricted. They can interact with trophoblast...
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Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages
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CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development
Studying the early function of essential genes is an important and challenging problem in developmental biology. Here, we established a method for rapidly inducing CRISPR-Cas9-mediated mutations in one blastom...
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Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome
PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRKAG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ...
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Epigenetic regulation of early neural fate commitment
Early neural fate commitment is a key process in neural development and establishment of the central nervous system, and this process is tightly controlled by extrinsic signals, intrinsic factors, and epigenet...
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Open AccessAF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation
AF9 mutations have been implicated in human neurodevelopmental diseases and murine Af9 mediates histone methylation during cortical neuron generation. However, AF9 function and related mechanisms in human neurode...
