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Chapter
Chromosomal Analysis of Spontaneous Hepatomas, a Derived Cell Line, and Chemically Induced Hepatomas in LEC Rats
Recent banding studies of chromosomes in a variety of human and animal tumors have provided a growing body of evidence that certain specific or nonrandom chromosomal changes are causally related to or closely ...
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Chapter
Hepatoma-Associated Alterations of Serum α1-Antitrypsin in LEC Rats
LEC rats have been established as a new mutant strain which develops hereditary hepatitis [1–3] and spontaneous hepatocellular carcinomas (hepatomas) [4]. However, the mechanisms of the development of the sequ...
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Chapter
Chromosomal Map** of the Placental Glutathione S-Transferase Gene and Its Expression in Livers of LEC Rats
The LEC strain rat is a new mutant which suddenly suffers from fulminant hepatitis at about 4 months of age [1, 2]. A crossing test of LEC rats showed that the hepatitis has an autosomal recessive mode of inhe...
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Chapter
High Susceptibility to Spontaneous Development of Hepatocellular Carcinoma in LEC Rats
Spontaneous hepatitis was first found in the LEC strain rat, which had been maintained conventionally at the Center for Experimental Plants and Animals, Hokkaido University [1]. The hepatitis appears suddenly ...
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Chapter
Combined Immunodeficiency in LEC Rats with Spontaneous Hepatitis
One of the abnormalities in the LEC rat is immunoglobulin G (IgG) formation, and a definite correlation has been found between suppressed IgG formation and the incidence of hepatitis [1, 2]. Therefore, we inve...
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Chapter
Progress from Chronic Hepatitis to Liver Cancer in Long-Surviving LEC Rats
In our previous papers, we reported on the clinical and pathological characteristics [1], pathogenesis [2], and combined immunodeficiency of spontaneous hepatitis in LEC rats.
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Chapter
Drug-Metabolizing Ability and Inducibility of Chromosomal Aberrations and Sister Chromatid Exchanges in LEC Rats Exposed to Cyclophosphamide
The LEC rat strain is a new mutant characterized by the spontaneous development of hepatitis with severe jaundice about 4 months of age [1, 2]. Genetic analysis demonstrated that the disease has an autosomal r...
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Chapter
Origin of the LEC Strain with a New Mutation Causing Hereditary Hepatitis
Over the last 10 years, a large number of animal models for human diseases has been discovered in laboratory mice and rats. Such model animals have become an indispensable tool in many fields of biological and...
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Chapter
Clinical and Pathological Characteristics of LEC Rats with Spontaneous Hepatitis
Currently, there are very few available animal models for the research of human hepatitis. We have known for many years that the marmoset and the chimpanzee are sensitive to hepatitis A and B viruses, respecti...
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Chapter
Investigation of Infectious Agents Causing Spontaneous Hepatitis in LEC Rats
Two strains of Long-Evans rats, LEC and LEA were separated according to their coat colors. Acute hepatitis tends to occur spontaneously in the LEC rats after the 24th generation. As has been previously reporte...
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Article
Euploid somatic recombinants with two active X or XY1Y2 chromosomes isolated from cultured male Indian muntjac cells after HVJ virus fusion, and their use for gene assignment
Four diploid somatic recombinants were isolated from hybrids either between or within two diploid cell lines of a male Indian muntjac after HVJ virus-mediated cell fusion. Both parental lines had a normal male...
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Article
Digynic triploidy after superovulation in mice
SUPEROVULATION through the administration of exogenous gonadotropins1 has been widely used in mice for experimental purposes, and cytogenetic evidence has shown2,4 that the technique does not affect adversely th...
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Article
Non-random inactivation of X chromosome in the rat yolk sac
THE Lyon hypothesis postulates that the mammalian female is a natural mosaic for clones of cells with either the maternally derived X chromosome (Xm) or the paternally derived one (Xp) which is randomly inactivat...
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Article
Unbalanced 13q/21q translocation: A revised study of the case previously reported as 21-monosomy
Reexamination was made on a male infant previously reported as 21-monosomy. Extensive chromosome banding analyses in the patient and parents disclosed an unbalanced de novo translocation between chromosomes 13...
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Article
Location of nucleolar organizers in animal and plant chromosomes by means of an improved N-banding technique
With an improved N-banding technique, the location of nucleolar organizing region was determined in 27 kinds of material including mammals, a marsupial, birds, amphibians, fishes, an insect and plants. In most...
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Article
Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse
RANDOM X inactivation makes the female mammal a natural mosaic for clones of cells having either the maternally derived X (Xm) or paternally derived one (Xp) which is genetically inactive1. There are, however, in...
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Article
An abortus with a normal/trisomy 16 mosaicism: instability of trisomic cells in vitro
A 46,XX/47,XX,+16 mosaicism was demonstrated in cultured chorionic cells obtained from an abortion material. By tracing polymorphic fluorescent chromosome markers in the abortus and the parents, the karyotypic...
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Article
A male infant with monosomy 21
A male infant with total monosomy 21 identified by Q-, G- and R-banding is described. His main symptoms are hypertonia, micrognathia, microphthalmus, imperforate anus, ambiguous external genitalia, floating an...
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Article
Chromosome banding patterns in an infant with 13q-syndrome
A case was described of a malformed male infant with partial monosomy for the long arm of chromosome 13. The chromosome banding and autoradiographic analyses revealed a 46,XY,del(13)(q22) karyotype as the most...
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Article
Differential Staining of Nucleolus Organisers in Mammalian Chromosomes
THE in situ DNA-RNA hybridisation techniques to locate a certain genome fraction with unique nucleotide sequences1–6 have assigned ribosomal cistrons to the satellites of human D and G group chromosomes4,5. This ...
