Abstract
The LEC strain rat is a new mutant which suddenly suffers from fulminant hepatitis at about 4 months of age [1, 2]. A crossing test of LEC rats showed that the hepatitis has an autosomal recessive mode of inheritance ruled by a single gene designated hts [3]. About 30% of the animals died of the disease within 1 week after onset. The remaining 70% survived with chronic hepatitis for more than 1 year and developed well-differentiated hepatocellular carcinomas (hepatomas) together with cholangiofibrosis at a remarkably high incidence [4]. Therefore, it is important to clarify what are the characteristics of hepatic lesions in LEC rats.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Sasaki M, Yoshida MC, Kagami K, Takeichi N, Kobayashi H, Dempo K, Mori M (1985) Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett 14:4–6.
Yoshida MC, Masuda R, Sasaki M, Takeichi N, Kobayashi H, Dempo K, Mori M (1987) New mutation causing hereditary hepatitis in the laboratory rat. J Hered 78:361–365.
Masuda R, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene. Lab Anim 22:166–169.
Masuda R, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis. Jpn J Cancer Res 79:828–835.
Kitahara A, Satoh K, Nishimura K, Ishikawa T, Ruike K, Sato K, Tsuda H, Ito N (1984) Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis. Cancer Res 44:2698–2703.
Sato K, Kitahara A, Satoh K, Ishikawa T, Tatematsu M, Ito N (1984) The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Jpn J Cancer Res 75:199–202.
Satoh K, Kitahara A, Soma Y, Inaba Y, Hatayama I, Sato K (1985) Purification, induction, and distribution of placental glutathione transferase: A new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc Natl Acad Sci USA 82:3964–3968.
Sugioka Y, Fujii-Kuriyama Y, Kitagawa T, Muramatsu M (1985) Changes in Polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis. Cancer Res 45:365–378.
Sugioka Y, Kano T, Okuda A, Sakai M, Kitagawa T, Muramatsu M (1985) Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA. Nucleic Acids Res 13:6049–6057.
Okuda A, Sakai M, Muramatsu M (1987) The structure of the rat glutathione S-transferase P gene and related pseudogenes. J Biol Chem 262:3858–3863.
Oyamada M, Dempo K, Fujimoto Y, Takahashi H, Satoh MI, Mori M, Masuda R, Yoshida MC, Satoh K, Sato K (1988) Spontaneous occurrence of placental glutathine S-transferase-positive foci in the livers of LEC rats. Jpn J Cancer Res 79:5–8.
Masuda R, Yoshida MC, Sasaki M, Okuda A, Sakai M, Muramatsu M (1986) Localization of the gene for glutathione S-transferase P on rat chromosome 1 at band q43. Jpn J Cancer Res 77:1055–1058.
Masuda R, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) A transplantable cell line derived from spontaneous hepatocellular carcinoma of the hereditary hepatitis LEC rat. Jpn J Cancer Res 79:250–254.
Masuda R, Yoshida MC, Sasaki M (1989) Gene expression of placental glutathione S-transferase in hereditary hepatitis and spontaneous hepatocarcinogenesis of LEC strain rats. Jpn J Cancer Res 80:1024–1027.
Sato K (1988) Glutathione S-transferases and hepatocarcinogenesis. Jpn J Cancer Res 79:556–572.
More MA, Fukushima S, Ichihara A, Sato K, Ito N (1986) Intestinal metaplasia and altered enzyme expression in propymitrosamine-induced Syrian hamster cholangiocellular and gallbladder lesions. Virchows Arch [B] 51:29–38.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Tokyo
About this chapter
Cite this chapter
Masuda, R., Yoshida, M.C., Sasaki, M. (1991). Chromosomal Map** of the Placental Glutathione S-Transferase Gene and Its Expression in Livers of LEC Rats. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_37
Download citation
DOI: https://doi.org/10.1007/978-4-431-68153-3_37
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68155-7
Online ISBN: 978-4-431-68153-3
eBook Packages: Springer Book Archive