8 Result(s)

Article

Biofilms harbour Clostridioides difficile, serving as a reservoir for recurrent infection

C. difficile infection (CDI) is a worldwide healthcare problem with ~30% of cases failing primary therapy, placing a burden on healthcare systems and increasing patient morbidity. We have little understanding of ...

Charmaine Normington, Ines B. Moura, Jessica A. Bryant… in npj Biofilms and Microbiomes (2021)

Article

V-Phaser 2: variant inference for viral populations

Massively parallel sequencing offers the possibility of revolutionizing the study of viral populations by providing ultra deep sequencing (tens to hundreds of thousand fold coverage) of complete viral genomes....

**ao Yang, Patrick Charlebois, Alex Macalalad, Matthew R Henn… in BMC Genomics (2013)

Article

De novo assembly of highly diverse viral populations

Extensive genetic diversity in viral populations within infected hosts and the divergence of variants from existing reference genomes impede the analysis of deep viral sequencing data. A de novo population consen...

**ao Yang, Patrick Charlebois, Sante Gnerre, Matthew G Coole… in BMC Genomics (2012)

Article

Draft genome sequence of the coccolithovirus EhV-84

The Coccolithoviridae is a recently discovered group of viruses that infect the marine coccolithophorid Emiliania huxleyi. Emiliania huxleyi virus 84 (EhV-84) has a 160–180 nm diameter icosahedral structure and a...

Jozef I. Nissimov, Charlotte A. Worthy, Paul Rooks… in Standards in Genomic Sciences (2011)

Article

Next-generation sequencing for HLA ty** of class I loci

Comprehensive sequence characterization across the MHC is important for successful organ transplantation and genetic association studies. To this end, we have developed an automated sample preparation, molecul...

Rachel L Erlich, **aoming Jia, Scott Anderson, Eric Banks, **aojiang Gao… in BMC Genomics (2011)

Article

Sensitive population profiling and genome assembly of HIV and Flaviviruses using ultra-deep sequencing technologies

Matthew R Henn, Niall J Lennon, Ruchi Newman, Patrick Charlebois… in Genome Biology (2010)

Article

A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454

We present an automated, high throughput library construction process for 454 technology. Sample handling errors and cross-contamination are minimized via end-to-end barcoding of plasticware, along with molecu...

Niall J Lennon, Robert E Lintner, Scott Anderson, Pablo Alvarez… in Genome Biology (2010)