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Article
Mutational processes shape the landscape of TP53 mutations in human cancer
Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein p53 (TP53) are missense mutations1,2. Mutant p53 protein is often abundantly expressed in cancers and specific allelic vari...
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Article
Open AccessA scalable, fully automated process for construction of sequence-ready barcoded libraries for 454
We present an automated, high throughput library construction process for 454 technology. Sample handling errors and cross-contamination are minimized via end-to-end barcoding of plasticware, along with molecu...
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Article
Open AccessLimited functional conservation of a global regulator among related bacterial genera: Lrp in Escherichia, Proteus and Vibrio
Bacterial genome sequences are being determined rapidly, but few species are physiologically well characterized. Predicting regulation from genome sequences usually involves extrapolation from better-studied b...
