32 Result(s)

Article

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled 14-Week Study of Mirogabalin in Chinese Patients with Diabetic Peripheral Neuropathic Pain

There is no approved effective drug for diabetic peripheral neuropathic pain (DPNP) in China. Gabapentinoids including mirogabalin have shown promise, although data in Chinese patients are scarce.

**aohui Guo, Yang Yu, Yongbo Zhang, Li Sun, Yufeng Li, Bing Song… in Pain and Therapy (2024)

Article

Prognosis of asymptomatic versus symptomatic metastatic breast cancer: a multicenter retrospective study

In Japan, asymptomatic metastatic breast cancer (MBC) is often detected using tumor markers or imaging tests. We aimed to investigate differences in clinicopathological features, prognosis, and treatment betwe...

Sayaka Kuba, Shigeto Maeda, Shigeki Minami, Hiroki Moriuchi… in Scientific Reports (2022)

Article

Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa… in Molecular Brain (2022)

Article

Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by specific social symptoms, restricted interests, stereotyped repetitive behaviors, and delayed language development. The 3q29 mi...

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa… in Molecular Brain (2022)

Article

Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia

An increasing body of evidence suggests that impaired synapse development and function are associated with schizophrenia; however, the underlying molecular pathophysiological mechanism of the disease remains l...

Kana Yamamoto, Toshihiko Kuriu, Kensuke Matsumura… in Translational Psychiatry (2021)

Article

Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZ^WT/Q1038R mouse model of autism spectrum disorder

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by core symptoms of impaired social behavior and communication. Recent studies have suggested that the oxytocin sy...

Kohei Kitagawa, Kensuke Matsumura, Masayuki Baba, Momoka Kondo… in Molecular Brain (2021)

Article

Results of Mirogabalin Treatment for Diabetic Peripheral Neuropathic Pain in Asian Subjects: A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Study

Almost one-quarter of Asian patients with diabetes experience diabetic peripheral neuropathic pain (DPNP), which may be associated with moderate or severe levels of pain, insomnia, mood disorders, and worsened...

Masayuki Baba, Masanori Kuroha, Shoichi Ohwada, Emiko Murayama… in Pain and Therapy (2020)

Article

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

Pogo transposable element derived with ZNF domain (POGZ) has been identified as one of the most recurrently de novo mutated genes in patients with neurodevelopmental disorders (NDDs), including autism spectrum di...

Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase… in Nature Communications (2020)

Article

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

3q29 microdeletion, a rare recurrent copy number variant (CNV), greatly confers an increased risk of psychiatric disorders, such as schizophrenia and autism spectrum disorder (ASD), as well as intellectual dis...

Masayuki Baba, Kazumasa Yokoyama, Kaoru Seiriki, Yuichiro Naka… in Neuropsychopharmacology (2019)