23 Result(s)

Article

Author Correction: Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher… in npj Parkinson's Disease (2024)

Article

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally modified forms accumulate in pa...

Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher… in npj Parkinson's Disease (2023)

Article

Correlation of magnetic resonance images with neuropathology of irreversible metronidazole-induced encephalopathy: an autopsy case report

Neurological symptoms and radiographic abnormalities may remain in a small proportion of patients with metronidazole-induced encephalopathy (MIE). Although experimental animal models of MIE have suggested a We...

Yasuo Miki, Yuki Takeuchi, Shingo Murasawa, Shinobu Takayasu… in BMC Neurology (2022)

Article

Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis

Conceição Bettencourt, Ignazio S. Piras… in Acta Neuropathologica Communications (2020)

Article

Early presentation of urinary retention in multiple system atrophy: can the disease begin in the sacral spinal cord?

Lower urinary tract (LUT) dysfunction presents early in multiple system atrophy (MSA), usually initially as urinary urgency, frequency and incontinence, and voiding difficulties/urinary retention becomes appar...

Jalesh N. Panicker, Sara Simeoni, Yasuo Miki, Amit Batla… in Journal of Neurology (2020)

Article

White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy

Multiple system atrophy (MSA) is a fatal late-onset neurodegenerative disease. Although presenting with distinct pathological hallmarks, which in MSA consist of glial cytoplasmic inclusions (GCIs) containing f...

Conceição Bettencourt, Sandrine C. Foti, Yasuo Miki, Juan Botia… in Acta Neuropathologica (2020)

Article

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studi...

Fumiaki Mori, Mari Tada, Tomoya Kon, Yasuo Miki… in Acta Neuropathologica Communications (2019)

Article

Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome

Clinical diagnosis of progressive supranuclear palsy (PSP) is sometimes difficult because various phenotypes have been identified. Here, we report a mutation in the bassoon (BSN) gene in a family with PSP-like sy...

Ichiro Yabe, Hiroaki Yaguchi, Yasutaka Kato, Yasuo Miki… in Scientific Reports (2018)

Article

Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy

The histological hallmark of multiple system atrophy (MSA) is the presence of filamentous aggregations of phosphorylated α-synuclein in oligodendrocytes, referred to as glial cytoplasmic inclusions (GCIs). Alt...

Keiko Nakamura, Fumiaki Mori, Tomoya Kon… in Acta Neuropathologica Communications (2015)

Article

Phosphorylation of serine 349 of p62 in Alzheimer’s disease brain

Extensive research on p62 has established its role in oxidative stress, protein degradation and in several diseases such as Paget’s disease of the bone, frontotemporal lobar degeneration and amyotrophic latera...

Kunikazu Tanji, Yasuo Miki, Taku Ozaki… in Acta Neuropathologica Communications (2014)

Article

The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis

Abnormal body temperatures (T_b) are frequently seen in patients with severe sepsis. However, the relationship between T_b abnormalities and the severity of disease is not clear. This study investigated the impact ...

Shigeki Kushimoto, Satoshi Gando, Daizoh Saitoh, Toshihiko Mayumi… in Critical Care (2013)

Article

A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis

To validate the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study at 15 cr...

Satoshi Gando, Daizoh Saitoh, Hiroshi Ogura, Seitaro Fujishima… in Critical Care (2013)