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Open AccessEpitope-specific immunity against Staphylococcus aureus coproporphyrinogen III oxidase
Staphylococcus aureus represents a serious infectious threat to global public health and a vaccine against S. aureus represents an unmet medical need. We here characterise two S. aureus vaccine candidates, coprop...
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Article
Open AccessCHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage
The BH3-only protein NOXA is a regulator of mitochondrial apoptosis by specifically antagonizing the anti-apoptotic protein MCL-1. Here we show that the E3 ubiquitin ligase CHIP controls NOXA stability after D...
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Article
Open AccessThe growth of Staphylococcus aureus and Escherichia coli in low-direct current electric fields
Electrical potentials up to 800 mV can be observed between different metallic dental restorations. These potentials produce fields in the mouth that may interfere with microbial communities. The present study ...
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Article
Open AccessTherapeutic concentrations of antibiotics inhibit Shiga toxin release from enterohemorrhagic E. coli O104:H4 from the 2011 German outbreak
The shiga toxin-producing E. coli (STEC) O104:H4 caused a major outbreak in Germany in spring 2011. STEC are usually susceptible to common antibiotics. However, antibiotic treatment of STEC-infected patients is n...
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Open AccessNOX enzymes as drug targets
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Open AccessLarge scale multiplex PCR improves pathogen detection by DNA microarrays
Medium density DNA microchips that carry a collection of probes for a broad spectrum of pathogens, have the potential to be powerful tools for simultaneous species identification, detection of virulence factor...
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Article
Open AccessGene transfer of Hodgkin cell lines via multivalent anti-CD30 scFv displaying bacteriophage
The display of binding ligands, such as recombinant antibody fragments, on the surface of filamentous phage makes it possible to specifically attach these phage particles to target cells. After uptake of the p...
