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  1. Article

    Open Access

    Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality

    The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal infla...

    Marie-Christine Albert, Iratxe Uranga-Murillo, Maykel Arias… in Cell Death & Differentiation (2024)

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  2. Article

    Open Access

    Primary cilia suppress Ripk3-mediated necroptosis

    Cilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated gene...

    Emilia Kieckhöfer, Gisela G. Slaats, Lena K. Ebert… in Cell Death Discovery (2022)

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  3. Article

    Open Access

    CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage

    The BH3-only protein NOXA is a regulator of mitochondrial apoptosis by specifically antagonizing the anti-apoptotic protein MCL-1. Here we show that the E3 ubiquitin ligase CHIP controls NOXA stability after D...

    Marie-Christine Albert, Kerstin Brinkmann, Wojciech Pokrzywa… in Cell Death & Disease (2020)

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  4. No Access

    Article

    Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

    Caspase-8 is the initiator caspase of extrinsic apoptosis1,2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality3, which can be rescued by del...

    Melanie Fritsch, Saskia D. Günther, Robin Schwarzer, Marie-Christine Albert… in Nature (2019)