Hagers Handbuch der Pharmazeutischen Praxis
Stoffe L-Z Folgeband 5
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Open AccessCombined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice
Transcriptional activation of target genes is essential for TP53-mediated tumour suppression, though the roles of the diverse TP53-activated target genes in tumour suppression remains poorly understood. Knockd...
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Cognitive effort in Schizophrenia: Dissimilar effects on cardiovascular activity and subjective effort
This study investigated objective and subjective cognitive effort as a function of task difficulty in schizophrenia, based on the principles of motivational intensity theory. Thirty individuals with schizophre...
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Implicit Motives in Sport and Exercise
Motives are traits of people that influence the way they perceive their environment. Motives provide the long-term energy for action, for example, in the domains of sport, exercise, and health. In this chapter...
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BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells
Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer, with treatment options often constrained due to inherent resistance of malignant cells to conventional therapy. We investig...
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What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?
In many human cancers the control of apoptosis is dysregulated, for instance as a result of the overexpression of pro-survival BCL-2 proteins. This promotes tumorigenesis by protecting nascent neoplastic cells...
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Open AccessSome mice lacking intrinsic, as well as death receptor induced apoptosis and necroptosis, can survive to adulthood
Programmed cell death, in particular the intrinsic apoptotic pathway, has been shown to play a critical role in the sha** of tissues during embryonic development. The multi-BCL-2 Homology (BH) domain effecto...
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Open AccessCHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage
The BH3-only protein NOXA is a regulator of mitochondrial apoptosis by specifically antagonizing the anti-apoptotic protein MCL-1. Here we show that the E3 ubiquitin ligase CHIP controls NOXA stability after D...
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miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells
The miR17~92 cluster plays important roles in haematopoiesis. However, it is not clear at what stage of differentiation and through which targets miR17~92 exerts this function. Therefore, we generated miR17~92fl/...
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Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis
Caspases exert critical functions in diverse cell death pathways, including apoptosis and pyroptosis, but some caspases also have roles in the processing of cytokines into their functional forms during inflamm...
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Open AccessVDAC2 enables BAX to mediate apoptosis and limit tumor development
Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated...
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The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice
A common therapeutic strategy to combat human cancer is the use of combinations of drugs, each targeting different cellular processes or vulnerabilities. Recent studies suggest that addition of an MCL-1 inhibi...
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Anhedonic symptoms of depression are linked to reduced motivation to obtain a reward
People with depression report reduced motivation to obtain a reward and reduced affective responses to reward. However, studies focusing on the relation between anhedonia and deficits in reward processing are ...
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I don’t care about others’ approval: Dysphoric individuals show reduced effort mobilization for obtaining a social reward
Past research on reduced reward responsiveness in depression and dysphoria has mainly focused on monetary rewards. However, social rewards are important motivators and might be especially impaired in depressio...
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Dysphorics can control depressive mood’s informational impact on effort mobilization
Individuals’ level of depression has been shown to systematically determine their amount of effort-related cardiovascular reactivity (see Brinkmann and Gendolla in Motiv Emot, 31:71–82, 2007; J Pers Soc Psychol, ...
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Ego involvement moderates the assimilation effect of affective expectations
Based on the affective expectations model and research on mental effort mobilization, two experiments manipulated affective expectations (no expectations versus positive expectations) and ego involvement (low ...
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Dysphoria and Mobilization of Mental Effort: Effects on Cardiovascular Reactivity
Two studies examined the influence of dysphoria on motivational intensity in a student sample. Participants worked on a memory task (Study 1) or a mental concentration task (Study 2) without fixed performance ...
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