5 Result(s)
within
Maria Thomas
Biomedicine, general
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Article
Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation
Tamoxifen (TAM) is commonly used for cell type specific Cre recombinase-induced gene inactivation and in cell fate tracing studies. Inducing a gene knockout by TAM and using non-TAM exposed mice as controls le...
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Article
Open AccessThe formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes
Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like ...
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Article
Comparative analysis of 3D culture methods on human HepG2 cells
Human primary hepatocytes represent a gold standard in in vitro liver research. Due to their low availability and high costs alternative liver cell models with comparable morphological and biochemical charact...
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Article
Open AccessThe truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes
The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative funct...
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Article
Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials
RNA interference has become an indispensable research tool to study gene functions in a wide variety of organisms. Because of their high efficacy and specificity, RNA interference-based approaches may also tra...
