-
Chapter
Kardiale, perioperative Risikobeurteilung
Die perioperative Risikoevaluation vor nichtkardialen operativen Eingriffen hat zum Ziel, kardiale Komplikationen zu vermeiden und damit die Prognose der Patienten zu verbessern. Im folgenden Kapitel beziehen ...
-
Living Reference Work Entry In depth
Kardiale, perioperative Risikobeurteilung
Die perioperative Risikoevaluation vor nichtkardialen operativen Eingriffen hat zum Ziel, kardiale Komplikationen zu vermeiden und damit die Prognose der Patienten zu verbessern. Im folgenden Kapitel beziehen ...
-
Article
Open AccessRisk modeling in transcatheter aortic valve replacement remains unsolved: an external validation study in 2946 German patients
Surgical risk prediction models are routinely used to guide decision-making for transcatheter aortic valve replacement (TAVR). New and updated TAVR-specific models have been developed to improve risk stratific...
-
Article
Open AccessAortic valve calcification is subject to aortic stenosis severity and the underlying flow pattern
Sex- and flow-related aortic valve calcification (AVC) studies are still limited in number, and data on the exact calcium quantity and distribution are scarce. Therefore, we aimed to (1) re-define the best thr...
-
Article
Open AccessDifferential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells
HepaRG cells are increasingly accepted as model for human drug metabolism and other hepatic functions. We used lentiviral transduction of undifferentiated HepaRG cells to deliver Cas9 and two alternative sgRNA...
-
Article
Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression
Structural variants including copy number variations (CNV) have gained widespread attention, especially in pharmacogenomics but for several genes functional relevance and clinical evidence are still lacking. D...
-
Article
Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels
Methyleugenol is a rodent hepatocarcinogen occurring in many herbs and spices as well as essential oils used for flavoring. Following metabolic activation by cytochromes P450 (CYPs) and sulfotransferases (SULT...
-
Article
Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms
In addition to its well-characterized role in the regulation of drug metabolism and transport by xenobiotics, pregnane X receptor (PXR) critically impacts on lipid homeostasis. In mice, both ligand-dependent ...
-
Article
Open AccessLyophilization protects [FeFe]-hydrogenases against O2-induced H-cluster degradation
Nature has developed an impressive repertoire of metal-based enzymes that perform complex chemical reactions under moderate conditions. Catalysts that produce molecular hydrogen (H2) are particularly promising fo...
-
Article
Open AccessThe truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes
The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative funct...
-
Article
„Was ist eigentlich das ‘Trans’?“
Lebenswelten von jungen Erwachsenen vervielfältigen sich. Eine grenzüberschreitende pluri-kontextuelle Zugehörigkeit von jungen Erwachsenen ist demzufolge keine Seltenheit mehr. Auch bei jungen Erwachsenen, de...
-
Chapter
„Social Capital Matters“ – als Ressource im bildungsbiographischen Verlauf der zweiten Generation
Einen Faden aufzugreifen, „der mit dem Rest zusammenhängt“, d.h. auf Ressourcen innerhalb eines sozialen Netzwerks zurückzugreifen und diese zu mobilisieren, stellt eine wichtige Ressource im Lebenslauf dar, d...
-
Article
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
We investigated the elimination routes for the 200 drugs that are sold most often by prescription count in the United States. The majority (78%) of the hepatically cleared drugs were found to be subject to oxi...
-
Article
Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene
Carboxylesterase 2 (CES2) is involved in the activation of the anticancer drug irinotecan to its active metabolite SN-38. We previously identified a single nucleotide polymorphism (SNP), with an allele frequen...
-
Article
Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C
Polymorphisms in the SLCO1B1 gene encoding the human hepatocellular uptake transporter OATP1B1 can be associated with alterations in transporter properties and may affect the pharmacokinetics of drugs transported...
