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Article
Microtubule lattice spacing governs cohesive envelope formation of tau family proteins
Tau is an intrinsically disordered microtubule-associated protein (MAP) implicated in neurodegenerative disease. On microtubules, tau molecules segregate into two kinetically distinct phases, consisting of eit...
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Protocol
In Vitro Reconstitution of Molecular Motor-Driven Mitochondrial Transport
Intracellular trafficking of organelles driven by molecular motors underlies essential cellular processes. Mitochondria, the powerhouses of the cell, are one of the major cargoes of molecular motors. Efficient...
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Article
Open AccessOptimization-driven framework to understand health care network costs and resource allocation
In the last several decades, the U.S. Health care industry has undergone a massive consolidation process that has resulted in the formation of large delivery networks. However, the integration of these network...
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Article
Open AccessAnillin propels myosin-independent constriction of actin rings
Constriction of the cytokinetic ring, a circular structure of actin filaments, is an essential step during cell division. Mechanical forces driving the constriction are attributed to myosin motor proteins, whi...
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Article
Strong genetic differentiation on a small geographic scale in the Neotropical rainforest understory tree Paypayrola blanchetiana (Violaceae)
Self-incompatible plants as well as common plant species are expected to be especially vulnerable to the deleterious effects of fragmentation on genetic diversity. Paypayrola blanchetiana (Violaceae) is a common,...
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Article
Open AccessMitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
Intracellular trafficking of organelles, driven by kinesin-1 step** along microtubules, underpins essential cellular processes. In absence of other proteins on the microtubule surface, kinesin-1 performs mic...
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Article
Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes
Tau is an intrinsically disordered protein, which diffuses on microtubules1. In neurodegenerative diseases, collectively termed tauopathies, malfunction of tau and its detachment from axonal microtubules are corr...
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Article
Development and characterization of eleven microsatellite loci for the tropical understory tree Paypayrola blanchetiana Tul. (Violaceae)
Microsatellites markers were developed for Paypayrola blanchetiana (Violaceae), a near-dispersing forest tree forming aggregated populations, to investigate genetic diversity and gene flow among subpopulations in...
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Article
Open AccessDiffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules
Form and function of the mitotic spindle depend on motor proteins that crosslink microtubules and move them relative to each other. Among these are kinesin-14s, such as Ncd, which interact with one microtubule...
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Article
Changes in microtubule overlap length regulate kinesin-14-driven microtubule sliding
Microtubule sliding driven by kinesin-14 HSET is regulated by a feedback mechanism. When microtubules start sliding apart, HSET molecules are retained in the shortening overlap, which leads to an HSET-density-...
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Article
Absence of pollinators and apomictic fruit production in an Atlantic rainforest population of Cymbopetalum brasiliense (Annonaceae)
Breeding system and pollination biology of an isolated population of Cymbopetalum brasiliense (Annonaceae), a large-flowered understory tree, was studied during two consecutive flowering seasons in October/Novemb...
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Article
Adaptive braking by Ase1 prevents overlap** microtubules from sliding completely apart
Overlap** antiparallel microtubules are important in cellular structures such as the mitotic spindle. Diez and colleagues use an in vitro system and mathematical modelling to show that the formation of stable o...
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Article
The kinesin-14 Klp2 organizes microtubules into parallel bundles by an ATP-dependent sorting mechanism
Kinesin-14 (Ncd in Drosophila, and Klp2 in fission yeast) is a microtubule-based motor important for spindle assembly. Ncd and Klp2 mediate both sliding of anti-parallel microtubules and crosslinking of parallel ...
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Chapter and Conference Paper
Computer-controlled noninvasive patient positioning in fractionated radiotherapy — A videogrammetric system for automatic patient setup, fast detection of patient motion and online correction of target point misalignment during therapy
Purpose An integrated videogrammetry based system for high precision fractionated radiotherapy in head and neck region has been developed. Patient setup is performed automatically and patient motion during treatm...
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Article
Unusual distribution of Ia-like antigens on canine lymphocytes
The murine monoclonal antibody 7.2, specific for a framework determinant of human Ia antigens, cross-reacts with canine cell membranes recognizing a bimolecular complex (29 000 and 34 000 daltons) similar to t...
