Skip to main content

and
  1. No Access

    Article

    Microtubule lattice spacing governs cohesive envelope formation of tau family proteins

    Tau is an intrinsically disordered microtubule-associated protein (MAP) implicated in neurodegenerative disease. On microtubules, tau molecules segregate into two kinetically distinct phases, consisting of eit...

    Valerie Siahaan, Ruensern Tan, Tereza Humhalova, Lenka Libusova in Nature Chemical Biology (2022)

  2. Article

    Open Access

    Anillin propels myosin-independent constriction of actin rings

    Constriction of the cytokinetic ring, a circular structure of actin filaments, is an essential step during cell division. Mechanical forces driving the constriction are attributed to myosin motor proteins, whi...

    Ondřej Kučera, Valerie Siahaan, Daniel Janda, Sietske H. Dijkstra in Nature Communications (2021)

  3. No Access

    Article

    Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

    Tau is an intrinsically disordered protein, which diffuses on microtubules1. In neurodegenerative diseases, collectively termed tauopathies, malfunction of tau and its detachment from axonal microtubules are corr...

    Valerie Siahaan, Jochen Krattenmacher, Anthony A. Hyman, Stefan Diez in Nature Cell Biology (2019)