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Article
Mobilization of peripheral blood stem cells for autologous transplant in non-Hodgkin's lymphoma and multiple myeloma patients by plerixafor and G-CSF and detection of tumor cell mobilization by PCR in multiple myeloma patients
This report describes the first investigational use of plerixafor in Europe and the determination of tumor cell mobilization by polymerase chain-reaction after plerixafor treatment in a subset of patients with...
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Article
Occurrence of donor-derived CLL 8 years after sibling donor SCT for CML
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Article
Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14)
Lack of CD56 expression was reported to be associated with a poor prognosis in multiple myeloma (MM) patients treated with conventional chemotherapy. Aim of our retrospective study was to analyse whether CD56 ...
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Article
Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma
The epidermal growth factor (EGF)/EGF-receptor (ErbB1-4) family is involved in the biology of multiple myeloma (MM). In particular, ErbB-specific inhibitors induce strong apoptosis of myeloma cells (MMC) in vitro
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Article
Stable mixed chimerism after T cell-depleted allogeneic hematopoietic stem cell transplantation using conditioning with low-dose total body irradiation and fludarabine
Although reduced intensity conditioning (RIC) before allografting is associated with low treatment-related morbidity and mortality, graft-versus-host disease (GVHD) remains a significant complication of hemato...
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Article
Anti-CD20 antibody as consolidation therapy in a patient with primary plasma cell leukemia after high-dose therapy and autologous stem cell transplantation
In multiple myeloma (MM), circulating malignant B cells are proposed as the proliferative compartment of the disease. In view of the close relationship between multiple myeloma and primary plasma cell leukemi...
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Article
Molecular monitoring of the tumor load predicts progressive disease in patients with multiple myeloma after high-dose therapy with autologous peripheral blood stem cell transplantation
The clinical relevance of the assessment of minimal residual disease (MRD) in patients with multiple myeloma (MM) to predict disease recurrence has not been proven. In the present study, we retrospectively ana...
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Article
Evaluation of the kinetics of the bone marrow tumor load in the course of sequential high-dose therapy assessed by quantitative PCR as a predictive parameter in patients with multiple myeloma
The aim of this investigation was to examine the possible clinical significance of the kinetics of bone marrow (BM) tumor load during the course of sequential high-dose therapy (HDT) as assessed by quantitativ...
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Article
CD19+ and CD20+ B cells from the peripheral blood of patients with multiple myeloma are not infected with human herpesvirus 8
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Chapter and Conference Paper
Zur Stellung „Sozialpsychiatrischer Dienste (SPDi)“ und Kliniken für Psychiatrie und Psychotherapie im „Gemeindepsychiatrischen Verbund (GPV)“ am Beispiel Bayreuth/Kulmbach in Oberfranken
Nach einer kurzen Skizze der Problematik stationärer und außerstationärer Versorgung wird auf die Sozialpsychiatrischen Dienste in Bayern und hier insbesondere in Oberfranken sowie auf deren Aufgabenstellung e...
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Article
Analysis of circulating tumor cells in patients with multiple myeloma during the course of high-dose therapy with peripheral blood stem cell transplantation
In multiple myeloma (MM) circulating CD19+ cells have been considered as myeloma precursors. As these cells are also possibly a reservoir of treatment resistant disease evaluation of the CD19+ cells during the co...
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Article
The remission status before and the PCR status after high-dose therapy with peripheral blood stem cell support are prognostic factors for relapse-free survival in patients with follicular non-Hodgkin’s lymphoma
It was the aim of our study to examine the clinical significance of t(14;18)-positive cells in samples from 47 patients with follicular non-Hodgkin’s lymphoma (NHL) who underwent high-dose therapy with autolog...
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Article
First and second apheresis in patients with multiple myeloma: no differences in tumor load and hematopoietic stem cell yield
Autologous peripheral blood stem cells (PBSC) are now widely used to support myeloablative therapy in patients with multiple myeloma (MM). The presence of malignant cells in these autografts has been demonstra...
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Chapter and Conference Paper
Myeloablative Hochdosistherapie mit Blutstammzellentransplantation bei Patienten mit zentroblastisch-zentrozytischem Non-Hodgkin-Lymphom
Zentroblastisch-zentrozytische (CB-CC-)Non-Hodgkin-Lymphome (NHL) werden nach der Kiel-Klassifikation [9] aufgrund pathomorphologischer Kriterien und ihres klinischen Verlaufes als niedrigmaligne eingestuft [1...
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Chapter and Conference Paper
Fluorescence In Situ Hybridization for the Diagnosis and Follow-up of BCR-ABL Positive ALL
The BCR-ABL fusion, which is the molecular counterpart of the t(9;22), is the most common genetic abnormality in adult acute lymphoblastic leukemia (ALL) [1]. Due to its important diagnostic and prognostic sig...
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Chapter and Conference Paper
Designing Probe Sets for the Detection of Chromosome Abnormalities in Acute Myeloid Leukemia Using Fluorescence In Situ Hybridization
In recent years, the karyotype as a prognostic factor in acute myeloid leukemia (AML) has gained considerable interest. Clonal chromosome aberrations are identified in 50–60% of patients with AML (for review s...
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Chapter and Conference Paper
Pseudomembranöse Kolitis — vom Krankheitsbild zum molekularen Verständnis der Wirkung der Clostridium difficile Toxine
Mit der Einführung von Makrolid-Antibiotika wie Clindamycin traten vermehrt schwere Darmerkrankungen auf [4, 5], die sich zunächst in Form von Durchfällen und im weiteren Verlauf als mitunter tödliche pseudome...
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Article
Detection of minimal tumor load in blood stem cell autografts in multiple myeloma: Steady-state versus high-dose chemotherapy stem cell mobilization
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Article
Abstract
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Chapter and Conference Paper
Erfahrungen mit kognitivem Training in der Behandlung chronischer Schizophrenien
In unserer Untersuchung wollten wir überprüfen, inwieweit das kognitive Trainingsprogramm bei an einer chronischen Schizophrenie leidenden Patienten wirksam ist. Im Unterschied zu anderen Untersuchungen fand u...
