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Article
Open AccessAntibody targeting of CD24 efficiently retards growth and influences cytokine milieu in experimental carcinomas
The targeting of cancer stem cells by monoclonal antibodies offers new options for therapy. CD24 is a glycosylphosphatidylinositol-anchored membrane protein with a small protein core and a high level of glycos...
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Article
Open AccessVEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma
Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found sp...
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Article
The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies
L1 cell adhesion molecule (L1-CAM) is a transmembrane cell adhesion molecule involved in cell migration and axon guidance in the develo** nervous system. L1 is also overexpressed in ovarian and endometrial c...
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Article
Anti-CD20 antibody as consolidation therapy in a patient with primary plasma cell leukemia after high-dose therapy and autologous stem cell transplantation
In multiple myeloma (MM), circulating malignant B cells are proposed as the proliferative compartment of the disease. In view of the close relationship between multiple myeloma and primary plasma cell leukemi...
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Article
CD19+ and CD20+ B cells from the peripheral blood of patients with multiple myeloma are not infected with human herpesvirus 8
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Article
Immediate effects of reversible HTLV-ITax function: T-cell activation and apoptosis
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Article
Three types of human lung tumour cell lines can be distinguished according to surface expression of endogenous urokinase and their capacity to bind exogenous urokinase
This study evaluates the cell surface expression of urokinase-type plasminogen activator (u-PA) and the capacity to bind exogenous urokinase as possible parameters for the distinction of various types of human...
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Article
Discordant differentiation antigen pattern in a case of Richter's syndrome with monoclonal idiotype expression and immunoglobulin gene rearrangement
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Article
Expression of epidermal growth factor receptor in benign and malignant primary tumours of the breast
Using the monoclonal antibody EGFR1, normal mammary gland and a series of 213 unselected primary breast tumours were investigated immunohistochemically for expression of epidermal growth factor receptor (EGFR)...
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Chapter and Conference Paper
Experimental Approaches to Tumor Therapy with Monoclonal Antibodies
Tumor targeting of therapeutically active substances using monoclonal antibodies (MAbs) as specific vehicles depends on a multitude of parameters, two of them being the subject of the present study: accessibil...
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Article
Reduction or loss of HLA-A,B,C antigens in colorectal carcinoma appears not to influence survival
Primary colorectal carcinomas of an unselected group of 159 patients 126 of whom could be curatively resected were examined for the expression of MHC class I antigens with monoclonal antibody W6/32 directed ag...
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Article
Epithelium-specific surface glycoprotein of Mr 34,000 is a widely distributed human carcinoma marker
An epithelial cell surface antigen is described which is defined by monoclonal antibody HEA125 (IgG1). The antibody was raised against the colon carcinoma cell line HT-29. Under reducing conditions HEA125 immu...
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Chapter and Conference Paper
Monoklonale Antikörper in der Tumordiagnostik und Tumortherapie
Seit langem ist versucht worden, tumorspezifische Antikörper herzustellen. Sowohl die Spontanregression mancher Tumore, die Infiltration des Tumors mit Leukozyten als auch der Nachweis von Antikörpern im Patie...
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Article
Detection of glucagon in pancreatic A-cells by monoclonal antibodies
The production of a mouse monoclonal antibody from a hybrid myeloma and its use for the detection of glucagon in tissue sections is reported. The hybrid clone isolated after fusion of mouse myeloma cells with ...
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Chapter and Conference Paper
Expression and Characterization of Leucocyte Antigens
In vitro translation and immunoprecipitation were used to identify messenger RNAs (mRNAs) coding for lymphocyte surface antigens. The mRNAs were extracted from human lymphoblastoid cell lines of B-cell or T-ce...
