23 Result(s)

Article

Effects of filaggrin breakdown products on the growth and maturation of keratinocytes

Filaggrin is degraded to amino acids in the stratum corneum. We tested the hypothesis that the resulting high concentrations of amino acids might be involved in the control of keratinocyte maturation. An amino...

J. Mansbridge, M. Knapp in Archives of Dermatological Research (1987)

Article

Prevalence of coeliac disease in diabetic children and adolescents

Screening for coeliac disease (CD) with serum antigliadin antibodies (AGA) was performed in 1032 diabetic children and adolescents. In 8 children CD had been diagnosed before study entry. Of the remaining 1024...

S. Koletzko, A. Bürgin-Wolff, B. Koletzko, M. Knapp… in European Journal of Pediatrics (1988)

Chapter and Conference Paper

Einfluß von Pestiziden auf die Funktion von Spermatozoen in vitro

Die Diskussion über einen möglichen Zusammenhang zwischen Umweltschadstoffen und einer Beeinträchtigung der Spermaqualität stützt sich bisher weitgehend auf statistische Daten (Schill 1986). In der vorliegende...

B. Roediger, H. van der Ven, H. Schlebusch, U. Wagner… in Gynäkologie und Geburtshilfe 1988 (1989)

Article

Einfluß von Pestiziden auf die Funktion von Spermatozoen in vitro

B. Roediger, H. van der Ven, H. Schlebusch… in Archives of Gynecology and Obstetrics (1989)

Chapter and Conference Paper

Analysis of Association in Nuclear Families

The major goal of association studies in genetics is to define risk haplotypes which may be responsible for the disease phenotype and to determine what kind of genetic control the marker system contributes to ...

S. A. Seuchter, M. Knapp, M. P. Baur in Recent Progress in the Genetic Epidemiolog… (1991)

Article

Schizophrenia: Shifting the balance of care

Schizophrenia poses a major challenge to policy makers in health and social care in England. As deinstitutionalisation has progressed, public concern about people with the condition has increased owing to a sm...

S. Kavanagh, L. Opit, M. Knapp… in Social Psychiatry and Psychiatric Epidemiology (1995)

Article

Human adenosine A_2a receptor (A_2aAR) gene: systematic mutation screening in patients with schizophrenia

Several lines of evidence suggest an involvement of adenosine A_2a receptor (A_2aAR) mediated adenosinergic neuromodulation in the etiopathogenesis of schizophrenia. We therefore perfomed a systematic mutation scan...

J. Deckert, M. M. Nöthen, M. Rietschel, D. Wildenauer… in Journal of Neural Transmission (1996)

Article

QALYs and mental health care

Quality-adjusted life year measures (QALYs) have been fervently debated by researchers and decision makers concerned with resource allocation in the health care sector. They have been heralded as important aid...

D. Chisholm, A. Healey, M. Knapp in Social Psychiatry and Psychiatric Epidemiology (1997)

Article

Systematic mutation screening and association study of the A₁ and A_2a adenosine receptor genes in panic disorder suggest a contribution of the A_2a gene to the development of disease

Several lines of evidence suggest a contribution of adenosinergic neurotransmission to the development of panic disorder. We therefore hypothesized that variation in the A₁ and A_2a adenosine receptor (AR) genes m...

J Deckert, M M Nöthen, P Franke, C Delmo, J Fritze, M Knapp… in Molecular Psychiatry (1998)

Article

Insertion/deletion variant (−141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder

A possible dysregulation of dopaminergic neurotransmission has been implicated in the aetiology of schizophrenic psychoses, in particular of paranoid-hallucinatory states, and of the manic episodes of bipolar...

G. Stöber, S. Jatzke, A. Heils, G. Jungkunz, M. Knapp… in Journal of Neural Transmission (1998)

Article

Does a hostel's managing agency determine the access to psychiatric services of its residents?

This study examines the effect of managing agency (local authority, private or voluntary) on the use of other health and social care services by residents in mental health hostels and group homes with differe...

B. Lucas, B. Audini, D. Chisholm, M. Knapp… in Social Psychiatry and Psychiatric Epidemio… (1998)

Chapter

Wirtschaftliche Evaluation der psychiatrischen Versorgung

Die enormen und anhaltenden persönlichen und sozialen Folgen psychischer Erkrankungen sind seit langem bekannt. Die Chronizität von Krankheiten wie Schizophrenic und Demenz und die zwar geringere, aber auch la...

M. Knapp in Psychiatrie der Gegenwart 1 (1999)

Article

Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios

A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy et al¹ using a case-control design with patients with...

O Wittekindt, S G Schwab, E Burgert, M Knapp, M Albus, B Lerer… in Molecular Psychiatry (1999)

Article

Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings

The serotonergic (5-HT) system has been implicated in the etiopathogenesis of psychoses. Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a c...

D Hranilovic, S G Schwab, B Jernej, M Knapp, B Lerer, M Albus… in Molecular Psychiatry (2000)

Article

DRD4 exon III VNTR polymorphism—susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach

Dopaminergic abnormalities are implicated in the pathogenesis of substance abuse.¹ Recently, two reports have been published suggesting an association between opioid dependence and presence of long alleles of the...

P Franke, M M Nöthen, T Wang, M Knapp, D Lichtermann, H Neidt… in Molecular Psychiatry (2000)

Article

Dopamine D₃ receptor variant and tardive dyskinesia

In the search for genetic factors contributing to tardive dyskinesia, dopamine receptor genes are considered major candidates. The dopamine D₃ receptor is of primary interest as dopamine D₃ receptor knock-out mi...

M. Rietschel, H. Krauss, D. J. Müller… in European Archives of Psychiatry and Clinic… (2000)

Article

Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1)

The dopamine transporter (DAT) plays a central role in dopaminergic neurotransmission in the human brain. Genetic association studies have used a variable number of tandem repeat (VNTR) polymorphism in the 3′-...

F Grünhage, T G Schulze, D J Müller, M Lanczik, E Franzek, M Albus… in Molecular Psychiatry (2000)

Article

Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach

Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. The activity of COMT is known to vary within the populat...

T Wang, P Franke, H Neidt, S Cichon, M Knapp, D Lichtermann… in Molecular Psychiatry (2001)

Chapter

Economic Evaluation of Mental Health Care

There has long been recognition of the enormous and persistent personal and social consequences of mental illness. The chronicity of disorders such as schizophrenia and dementia, and the long-term if lower-lev...

M. Knapp in Contemporary Psychiatry (2001)

Article

Risikostratifizierung in der Herzchirurgie bei Patienten im Alter von achtzig Jahren und älter

Outcome nach Herzoperationen hat zunehmend für Herzchirurgen und für die Öffentlichkeit an Bedeutung gewonnen. Qualitätsverbesserungen und Outcome können durch präoperative Risiken stratifiziert werden.¶   Di...

R. Driever, A. Tietz, M. Knapp, H. O. Vetter in Zeitschrift für Herz-, Thorax- und Gefäßch… (2001)