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Article
Electroconvulsive therapy resolves cortical inhibition and manneristic omissions in a chronic catatonic patient
We investigated a patient with severe catatonic schizophrenia (manneristic catatonia according to Karl Leonhard) treated with electroconvulsive therapy (ECT) after pharmacological approaches did not result in ...
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Article
Sind zykloide Psychosen atypische manisch-depressive Erkrankungen?
Zykloide Psychosen (ZP) stellen klinisch sowohl von schizophrenen als auch von affektiven Psychosen abgrenzbare Erkrankungen dar. Bislang fehlen jedoch methodisch befriedigende Daten zur nosologischen Abgrenz...
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Article
Sind zykloide Psychosen atypische manisch-depressive Erkrankungen?
Zykloide Psychosen (ZP) stellen klinisch sowohl von schizophrenen als auch von affektiven Psychosen abgrenzbare Erkrankungen dar. Bislang fehlen jedoch methodisch befriedigende Daten zur nosologischen Abgrenz...
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Article
Vergleichsuntersuchung zur Lebensqualität bei Probanden mit zykloiden und schizophrenen Psychosen
Zykloide Psychosen repräsentieren eine klinisch gut charakterisierte, jedoch wenig beachtete Krankheitsgruppe. Sie zeigen auch nach protrahierten Episoden volle Remission und haben daher eine günstige Prognose.
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Article
Mutation analysis of the zinc transporter gene SLC30A4 reveals no association with periodic catatonia on chromosome 15q15
The zinc transporter gene SLC30A4, located on chromosome 15q15-q21, has previously been reported to show altered expression patterns in post mortem analysis of the brains of schizophrenic patients. As a position...
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Article
Exposure to prenatal infections, genetics and the risk of systematic and periodic catatonia
The meaning of heterogeneity in schizophrenia and the impact of genetic and environmental factors on etiology are a matter of continuous debate in psychiatric research. Different clinical and birth history va...
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Article
Cycloid psychoses – from clinical concepts to biological foundations
The modern concept of cycloid psychoses is primarily based upon the clinical delineation of their phenotypes according to Leonhard. By settling the dilemma of Kraepelinean “atypical psychoses”, their descript...
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Article
No missense mutation of WKL1 in a subgroup of probands with schizophrenia
Recently, a Leu309Met mutation in WKL1 (MLC1, KIAA0027), a gene mapped to chromosome 22q13.33, was reported to co-segregate with periodic catatonia, a clinical sub-type of schizophrenia, in seven members of an ex...
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Article
Exclusion of the neuronal nicotinic acetylcholine receptor α7 subunit gene as a candidate for catatonic schizophrenia in a large family supporting the chromosome 15q13–22 locus
The gene encoding the neuronal nicotinic acetylcholine receptor α7 subunit (CHRNA7) is located on chromosome 15q13.2. This region was suggested to be involved in the etiopathogenesis of: (a) schizophrenia combine...
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Article
Disturbed neural circuits in a subtype of chronic catatonic schizophrenia demonstrated by F-18-FDG-PET and F-18-DOPA-PET
Permanent verbal, visual scenic and coenaestetic hallucinations are the most prominent psychopathological symptoms aside from psychomotor disorders in speech-sluggish catatonia, a subtype of chronic catatonic...
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Article
A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree
Schizophrenia is a common and etiologically heterogeneous disorder. Although inheritance of schizophrenic syndromes is complex with genetic and environmental factors contributing to the clinical phenotype, per...
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Article
Differenzierte Diagnostik, Verlauf und Ausgang postpartaler Psychosen Eine katamnestische Untersuchung
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Article
Zykloide Psychosen und die empirisch-statistische Forschung Anmerkungen zum Beitrag von D. Sigmund Nervenarzt (1998) 69: 228–237
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Article
Isolierte Aplasie des Septum pellucidum bei einem hebephrenen Patienten
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Article
Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression
Transcriptional activity of the human serotonin transporter gene (5HTT) is modulated by complex interaction of multiple genomic and cellular factors. Variability of a polymorphic repetitive element (5HTTLPR) is ...
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Article
Cloning and functional characterization of the human norepinephrine transporter gene promoter
The norepinephrine transporter (NET) plays a critical role in brain norepinephrine homeostasis and is a target for antidepressants and drugs of abuse. We have analyzed the 5'flanking regulatory region of the ...
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Article
Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene
A possible dysregulation of serotonergic neurotransmission has been implicated in the aetiology of schizophrenic psychoses. In the present study we analysed allelic and genotypic variations of a recently desc...
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Article
Insertion/deletion variant (−141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder
A possible dysregulation of dopaminergic neurotransmission has been implicated in the aetiology of schizophrenic psychoses, in particular of paranoid-hallucinatory states, and of the manic episodes of bipolar...
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Article
Die Kataphasie: eine durch formale Denkstörungen und sprachliche Auffälligkeiten gekennzeichnete Psychose des schizophrenen Formenkreises
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Chapter and Conference Paper
Granulozytäre Omega-3-Rezeptoren bei Erkrankungen aus dem schizophrenen Formenkreis: Zusammenhänge mit klinischer Symptomkonstellation
In den letzten Jahren gewannen die sogenannten Omega-3-Rezeptoren (früher: Benzodiazepinrezeptoren vom „peripheren“ Typ), die insbesondere an der äußeren Mitochondrienmembran verschiedener Gewebe (z. B. Gliaze...