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  1. No Access

    Article

    Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach

    Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. The activity of COMT is known to vary within the populat...

    T Wang, P Franke, H Neidt, S Cichon, M Knapp, D Lichtermann… in Molecular Psychiatry (2001)

  2. No Access

    Article

    DRD4 exon III VNTR polymorphism—susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach

    Dopaminergic abnormalities are implicated in the pathogenesis of substance abuse.1 Recently, two reports have been published suggesting an association between opioid dependence and presence of long alleles of the...

    P Franke, M M Nöthen, T Wang, M Knapp, D Lichtermann, H Neidt… in Molecular Psychiatry (2000)