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Chapter
Forensische Serologie/Hämogenetik
Die forensische Serologie ist eine der tragenden Säulen des Fachgebietes Rechtsmedizin.
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Article
A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25–q26
In an attempt to identify susceptibility loci for bipolar affective disorder, we are currently conducting a systematic genome screen with highly polymorphic microsatellite markers at an average marker spacing ...
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Article
Strauch et al reply
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Chapter and Conference Paper
Computerunterstützte telemedizinische Operationsassistenz — Darstellung und Bewertung neuer Möglichkeiten am Beispiel einer japanisch-deutschen Kooperation
Tele- and computer-assisted surgery has to solve three main problems: to integrate preoperative diagnostic results, secure transmission between the participants and provide visual and tactile information for a...
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Article
Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families
Previously reported linkage of bipolar affective disorder to DNA markers on chromosome 18 was reexamined in a large sample of German bipolar families. Twenty-three short tandem repeat markers were investigated...
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Article
Likelihood ratios for mixed stains when the number of donors cannot be agreed
Suppose that part of the prosecution's evidence in some crime case is analysis of a blood stain, and that the traits E discovered in the stain suggest multiple donors. Then the prosecution will probably allege...
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Article
DNA-minisatellite mutations: Recent investigations concerning distribution and impact on parentage testing
At least 815 meioses were studied in theHinfI polymorphisms of DNA minisatellite loci D1S7, D2S44, D7S21, D7S22, and D12S11 in order to collect data on respective mutation rates. At locus D7S21 (probe MS31) a str...
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Chapter and Conference Paper
Comparison of Minisatellite DNA Probes and Blood Group, Protein, and Enzyme Markers in Paternity Cases
Multilocus and single locus minitsatellite probes have been applied to the paternity expertise for some time (Jeffreys et al., 1985; Dykes et al., 1988; Henke et al., 1990; Jeffreys et al., 1991). They are now...
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Chapter and Conference Paper
Comparison of Different Methods for the Calculation of Indices of Paternity
The qualitative decision about paternity in trio cases on the basis of DNA multilocus profiles is no problem. If there are more than 1 or 2 exclusion patterns (band present in child, which is neither present i...
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Chapter and Conference Paper
How to Deal with Mutations in DNA-Testing
Some of the DNA single locus polymorphisms, which are presently used in paternity testing have a comparably high mutation rate. Consequently changes in fragment size occur quite often, during the transmission ...
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Chapter and Conference Paper
A Comprehensive Pedigree Analysis Tool: FAP (Family Analysis Package)
A major problem in genetic epidemiology is the analysis of human pedigrees. The purpose of this analysis may be to determine the mode of inheritance of a disease, to test linkage, or to calculate risk factors ...
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Chapter and Conference Paper
Analysis of Association in Nuclear Families
The major goal of association studies in genetics is to define risk haplotypes which may be responsible for the disease phenotype and to determine what kind of genetic control the marker system contributes to ...
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Article
Inheritance of some electrophoretic phenotypes of human hair
Four isokeratin patterns were demonstrated by means of one-dimensional SDS electrophoresis of low sulfur proteins in human hair. The phenotypes had the following frequencies: K1 = 69.70%, K1m = 18.18%, K3 = 9....
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Chapter and Conference Paper
Inheritance of Some Electrophoretic Phenotypes of Human Hair
The method used was a one-dimensional SDS electrophoresis of low sulfur proteins in the presence of urea which was developed by Gerhard (1987). Hairs of 5 families with 3 or 4 generations and 6 to 56 members w...
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Chapter and Conference Paper
Likelihood Calculations in Paternity Testing on the Basis of DNA-Fingerprints
DNA-fingerprints seem to be a powerful tool in paternity testing. But the quantification of the results in terms of likelihood and likelihood ratios is a problem, because in most cases the correct genetic mode...
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Article
Schwangerschaftsspezifisches Protein 1 (SP1) im mütterlichen Serum zur Überwachung der Frühstschwangerschaft mit Hilfe eines Regressionsmodells
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Article
Extended polymorphism of the human esterase D isozyme system: description of a “new” allele EsD*11
Using “new” techniques (malic acid thin layer agarose gel electrophoresis and/or isoelectric focusing), the polymorphism of the human red cell isozyme system esterase D (ESD) was shown to be extended. We repor...
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Chapter and Conference Paper
Analysis of Multilocus Pedigree Data by Computer
Pedigree analysis is a methodology used for gene map**, risk prediction in genetic counseling, hypothesis testing in genetic epidemiology, and parameter estimation of genetic models. Therefore, mendelian lik...
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Chapter and Conference Paper
Reference Tables of Three-Locus Haplotype Frequencies and Delta Values in Caucasians, Orientals, and Negroids
The frequencies given were determined by haplotype counting based on the results of the FAP [1]. The selection criteria were the same as those used for the production of the gene frequencies and the two-point ...
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Chapter and Conference Paper
Cell Ty** by Computer
For the Ninth International Histocompatibility Workshop, a computer cell ty** program was developed, as was done for the previous Workshop. Its main purpose was to assign phenotypes to all individuals submit...
