20 Result(s)
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Open AccessHOMA-IR and the Matsuda Index as predictors of progression to type 1 diabetes in autoantibody-positive relatives
We assessed whether HOMA-IR and the Matsuda Index are associated with transitions through stages of type 1 diabetes.
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Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Islet autoantibodies (AAbs) are detected in >90% of individuals with clinically suspected type 1 diabetes at disease onset. A single AAb, sometimes at low titre, is often detected in some individuals, making t...
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Dysglycemia after COVID-19 pneumonia: a six-month cohort study
The aim of this study was to understand whether the dysglycemia associated with SARS-CoV-2 infection persists or reverts when the viral infection resolves.
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Felix dies natalis, insulin… ceterum autem censeo “beta is better”
One hundred years after its discovery, insulin remains the life-saving therapy for many patients with diabetes. It has been a 100-years-old success story thanks to the fact that insulin therapy has continuousl...
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Open AccessThe hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells
Neonatal beta cells carry out a programme of postnatal functional maturation to achieve full glucose responsiveness. A partial loss of the mature phenotype of adult beta cells may contribute to a reduction of ...
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Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study
The aim of the study was to characterise the humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with diabetes. Demonstrating the ability to mount an appropriate a...
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Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer
More than 40% of pancreatic ductal adenocarcinoma (PDAC) patients have glucose intolerance or diabetes. The association has led to two hypotheses: PDAC causes diabetes or diabetes shares risk factors for the d...
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Insulin-mimetic effects of short-term rapamycin in type 1 diabetic patients prior to islet transplantation
The immunosuppressive drug rapamycin may influence insulin sensitivity in insulin-responsive tissues.
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Defining outcomes for beta cell replacement therapy: a work in progress
Defined outcomes for beta cell replacement therapy in the treatment of diabetes are critically needed. Progress towards the clinical acceptance of pancreas and islet transplantation has been hampered by the la...
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A novel LIPS assay for insulin autoantibodies
Insulin autoantibodies (IAA) are often the first marker of autoimmunity detected in children in the preclinical phase of type 1 diabetes (T1D). Currently, the vast majority of laboratories adopt the radiobindi...
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Autoantibody binding in liquid phase to IL-2 in human sera is not type 1 diabetes specific
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Ultra-marathon 100 km in an islet-transplanted runner
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MicroRNA expression profiles of human iPSCs differentiation into insulin-producing cells
MicroRNAs are a class of small noncoding RNAs, which control gene expression by inhibition of mRNA translation. MicroRNAs are involved in the control of biological processes including cell differentiation. Her...
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Insulin resistance is associated with the aggressiveness of pancreatic ductal carcinoma
To study whether insulin resistance accelerates the development and/or the progression of pancreatic adenocarcinoma (PDAC), we hypothesized that patients with insulin resistance, compared with those without in...
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The state of the art of islet transplantation and cell therapy in type 1 diabetes
In patients with type 1 diabetes (T1D), pancreatic β cells are destroyed by a selective autoimmune attack and their replacement with functional insulin-producing cells is the only possible cure for this diseas...
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Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo
New sources of insulin-secreting cells are strongly required for the cure of diabetes. Recent successes in differentiating embryonic stem cells, in combination with the discovery that it is possible to derive ...
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Human islet distribution programme for basic research: activity over the last 5 years
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Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment
NMDA receptors in pancreatic beta cells inhibit glucose-stimulated insulin secretion, and inhibiting these receptors with an over-the-counter medication improves diabetes in mouse models
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Clinical signature and pathogenetic factors of diabetes associated with pancreas disease (T3cDM): a prospective observational study in surgical patients
To characterize the clinical signature and etiopathogenetic factors of diabetes associated with pancreas disease [type 3 diabetes mellitus (T3cDM)]. To estimate incidence and identify predictors of both diabe...
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Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up
Type 2 diabetes is associated with risk of cancer. Hyperinsulinemia and insulin resistance may be the link with cancer, but whether this is independent of the diabetes status, obesity/visceral obesity and meta...
