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  1. Article

    Open Access

    Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway

    Cellular senescence is a hallmark of aging and has been linked to age-related diseases. Age-related macular degeneration (AMD), the most common aging-related retinal disease, is prospectively associated with r...

    Hong-Ying Li, Ting-Ting Wei, Miao Zhuang, Cheng-Ye Tan… in Cell Death Discovery (2023)

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  2. Article

    Open Access

    TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy

    Diabetic retinopathy (DR) is a serious and relatively under-recognized complication of diabetes. Müller glial cells extend throughout the retina and play vital roles in maintaining retinal homeostasis. Previou...

    Yan Li, Lingpeng Zhu, Meng-**a Cai, Zi-Li Wang, Miao Zhuang… in Cell Death & Disease (2023)

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  3. No Access

    Article

    Suppressing Receptor-Interacting Protein 140: a New Sight for Salidroside to Treat Cerebral Ischemia

    The purpose of the current study was to detect the effect of salidroside (Sal) on cerebral ischemia and explore its potential mechanism. Middle cerebral artery occlusion (MCAO) was performed to investigate the...

    Tong Chen, Zhanqiang Ma, Lingpeng Zhu, Wenjiao Jiang… in Molecular Neurobiology (2016)

  4. No Access

    Article

    Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway

    Age-related inflammation is the predominant factor for neurodegenerative diseases like Alzheimer’s disease (AD). In the present study, we examined memory performance and neuroinflammation in D-galactose (D-gal...

    ** Gao, Rui Zhou, **ntong You, Fen Luo, He He, **ayun Chang… in Metabolic Brain Disease (2016)

  5. No Access

    Article

    Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3β Signaling

    Sepsis-induced myocardial injury (SIMI) is caused by various mechanisms. The aim of this study was to investigate the effects of salidroside (Sal) on SIMI and its mechanisms in rats. The sepsis model was estab...

    He He, **ayun Chang, ** Gao, Lingpeng Zhu, Mingxing Miao, Tianhua Yan in Inflammation (2015)

  6. No Access

    Article

    The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation

    The main purpose of this study was to investigate effect of salidroside (Sal) on myocardial ischemia reperfusion injury in rats and the underlying mechanism. Myocardial ischemia reperfusion injury (MI/RI) mode...

    Lingpeng Zhu, Tingting Wei, ** Gao, **ayun Chang, He He, Fen Luo, Rui Zhou… in Apoptosis (2015)

  7. No Access

    Article

    Anti-Asthmatic Effects of Ginsenoside Rb1 in a Mouse Model of Allergic Asthma Through Relegating Th1/Th2

    The aim of the study was to investigate the anti-asthma effects of ginsenoside Rb1 (Rb1) and its possible mechanisms. A total of 50 mice were randomly assigned to five experimental groups: control, model, dexa...

    Tong Chen, Lu **ao, Lingpeng Zhu, Shi** Ma, Tianhua Yan, Hui Ji in Inflammation (2015)

  8. No Access

    Article

    Effects of Salidroside on Myocardial Injury In Vivo In Vitro via Regulation of Nox/NF-κB/AP1 Pathway

    Salidroside (Sal), a phenylpropanoid glycoside isolated from a popular traditional Chinese medicinal plant Rhodiola rosea L., possesses multiple pharmacological actions. This aim of this study is to investigate t...

    Lingpeng Zhu, Tingting Wei, **ayun Chang, He He, ** Gao, Zhengli Wen… in Inflammation (2015)

  9. No Access

    Article

    The Effect of Synthetic Salidroside on Cytokines and Airway Inflammation of Asthma Induced by Diisocyanate (TDI) in Mice by Regulating GATA3/T-bet

    This study was conducted to explore the anti-asthma effects of synthetic salidroside on cytokines and airway inflammation of asthma induced by diisocyanate (TDI) in mice. The experiment was carried out 60 fema...

    **g Wang, Lu **ao, Lingpeng Zhu, Mei Hu, Qiujuan Wang, Tianhua Yan in Inflammation (2015)

  10. No Access

    Article

    Effects of Naringenin on Inflammation in Complete Freund’s Adjuvant-Induced Arthritis by Regulating Bax/Bcl-2 Balance

    Naringin (COG) is a flavanone with various bioactivities including an expectorant effect, antitussive effect, and inhibitory effect on asthma and acute lung injury. The aims of the present study were to invest...

    Lingpeng zhu, **g Wang, Tingting Wei, ** Gao, He He, **ayun Chang… in Inflammation (2015)

  11. No Access

    Article

    Anti-Inflammatory Effects of Apigenin in Lipopolysaccharide-Induced Inflammatory in Acute Lung Injury by Suppressing COX-2 and NF-kB Pathway

    This study aims to evaluate the possible mechanisms responsible for the anti-inflammatory effects of apigenin lipopolysaccharide (LPS)-induced inflammatory in acute lung injury. In this study, the anti-inflamm...

    **g Wang, Yu-Tao Liu, Lu **ao, Lingpeng Zhu, Qiujuan Wang, Tianhua Yan in Inflammation (2014)