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Article
Open AccessCIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lu...
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Article
Open AccessDiagnostic value of multiple b-value diffusion-weighted imaging in discriminating the malignant from benign breast lesions
The conventional breast Diffusion-weighted imaging (DWI) was subtly influenced by microcirculation owing to the insufficient selection of the b values. However, the multiparameter derived from multiple b-value...
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Article
Apatinib, a novel VEGFR inhibitor plus docetaxel in advanced lung adenocarcinoma patients with wild-type EGFR: a phase I trial
Background This phase I trial was primarily conducted to determine the maximum tolerated dose (MTD) of apatinib combined with docetaxel in advanced lung adenocarcinoma patients with wild-type EGFR who have failed...
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Article
SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson’s disease in Chinese population
Recently, rs2421947 in DNM3 (dynamin 3) was reported as a genetic modifier of age at onset (AAO) of LRRK2 G2019S-related Parkinson’s disease (PD) in a genome-wide association study in Arab-Berber population. Rs35...
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Article
Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro
Suxiao Jiuxin pill (SJP) is a traditional Chinese medicine for the treatment of acute coronary syndrome in China, which contains two principal components, tetramethylpyrazine (TMP) and borneol (BOR). Thus far,...
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Article
Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro
Cardiac mesenchymal stem cells (C-MSCs) are endogenous cardiac stromal cells that play a role in heart repair after injury. C-MSC-derived exosomes (Exo) have shown protective effects against apoptosis induced ...
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Article
SplitPass: A Mutually Distrusting Two-Party Password Manager
Using a password manager is known to be more convenient and secure than not using one, on the assumption that the password manager itself is safe. However recent studies show that most popular password manager...
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Article
Anti-Inflammatory Effects of Apigenin in Lipopolysaccharide-Induced Inflammatory in Acute Lung Injury by Suppressing COX-2 and NF-kB Pathway
This study aims to evaluate the possible mechanisms responsible for the anti-inflammatory effects of apigenin lipopolysaccharide (LPS)-induced inflammatory in acute lung injury. In this study, the anti-inflamm...
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Article
Immunohistochemistry reliably detects ALK rearrangements in patients with advanced non-small-cell lung cancer
Accurate determination of anaplastic lymphoma kinase (ALK) rearrangements is critical in identifying ALK-positive patients for targeted therapy in non-small-cell lung cancer (NSCLC). Fluorescence in situ hybri...
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Article
Implementation and design of a communication system of an agent-based automated substation
A substation system requires that communication be transmitted reliably, accurately and in real-time. Aimed at solving problems, e.g., flow confliction and sensitive data transmission, a model of the communica...
