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Article
Open AccessEmbryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms
Social affective and communication symptoms are central to autism spectrum disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display improving abilities across early ages and d...
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Article
Open AccessA predictive ensemble classifier for the gene expression diagnosis of ASD at ages 1 to 4 years
Autism Spectrum Disorder (ASD) diagnosis remains behavior-based and the median age of diagnosis is ~52 months, nearly 5 years after its first-trimester origin. Accurate and clinically-translatable early-age di...
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Article
Open AccessPre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism
Early detection and intervention are believed to be key to facilitating better outcomes in children with autism, yet the impact of age at treatment start on the outcome is poorly understood. While clinical tra...
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Article
Open AccessMultiple freeze-thaw cycles lead to a loss of consistency in poly(A)-enriched RNA sequencing
Both RNA-Seq and sample freeze-thaw are ubiquitous. However, knowledge about the impact of freeze-thaw on downstream analyses is limited. The lack of common quality metrics that are sufficiently sensitive to f...
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Article
A perturbed gene network containing PI3K–AKT, RAS–ERK and WNT–β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity
Hundreds of genes are implicated in autism spectrum disorder (ASD), but the mechanisms through which they contribute to ASD pathophysiology remain elusive. Here we analyzed leukocyte transcriptomics from 1- to...
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Article
Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes
Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between ...
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Article
A Case Control Study of the Implementation of Change Model Versus Passive Dissemination of Practice Guidelines for Compliance in Monitoring for Metabolic Syndrome
We developed an intervention to improve compliance with guidelines for monitoring metabolic syndrome and compared compliance prior to intervention and three times post-intervention at three community mental he...
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Article
Community Mental Health Agency Views of Research
We examined community mental health center staff perceptions of ongoing research within their agency. We interviewed upper management and conducted focus groups with medical staff, non-medical clinicians, and ...
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Article
Barriers to, and Strategies for, Starting a Long Acting Injection Clinic in a Community Mental Health Center
As many as 50% of patients with schizophrenia do not take oral antipsychotic medications as prescribed, yet long acting injections are rarely utilized. Community agencies that serve this population are often o...
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A Roll-off Roof Observatory in New Boston, New Hampshire, USA
This is the third observatory we have built since we purchased our first telescope in 1983. It is 12 ft × 16 ft (3.6 m × 5 m) with a roll-off roof. We decided to build the observatory ourselves due to money co...
