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Open AccessDifferences in regional brain structure in toddlers with autism are related to future language outcomes
Language and social symptoms improve with age in some autistic toddlers, but not in others, and such outcome differences are not clearly predictable from clinical scores alone. Here we aim to identify early-ag...
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Article
Transcriptomic Analysis of Cyclamen persicum to Identify Invovled Genes in Triterpene Secondary Metabolites Pathway
Saponins are considered as a diverse group of natural active compounds, which are widely found in crops. Mevalonate pathway (MVA) is regarded as the main pathway for synthesis of saponins in crops. This study ...
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Open AccessPredictive three-biomarker panel in peripheral blood mononuclear cells for detecting hepatocellular carcinoma
Hepatocellular carcinoma (HCC) ranks among the most prevalent cancers and accounts for a significant proportion of cancer-associated deaths worldwide. This disease, marked by multifaceted etiology, often poses...
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Article
Open Access123VCF: an intuitive and efficient tool for filtering VCF files
The advent of Next-Generation Sequencing (NGS) has catalyzed a paradigm shift in medical genetics, enabling the identification of disease-associated variants. However, the vast quantum of data produced by NGS ...
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Article
Computational prediction of protein–protein interactions’ network in Arabidopsis thaliana
The study of protein–protein interactions (PPIs) has been a major factor in understanding the function of proteins. The development of diverse methodologies currently facilitates the identification of novel or...
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Article
Correction to: Efficiency of monolayers in evaporation suppression from water surface considering meteorological parameters
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Efficiency of monolayers in evaporation suppression from water surface considering meteorological parameters
The evaporation from water reservoirs has become a global issue due to climate change, limited water resources, and population growth. In this research, three emulsions of octadecanol/Brij-35 (4:1), hexadecano...
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RNA-Seq Analyzing Reveals the Key Role of SVR3 Gene in Tolerating the Freezing Stress in Saccharum spontaneum
Wild sugarcane, Saccharum spontaneum, is a cold-tolerant species, and cultivated S. officinarum is highly sensitive to cold stress. The present study aimed at identifying genes and mechanisms acting in stress con...
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Article
Open AccessA predictive ensemble classifier for the gene expression diagnosis of ASD at ages 1 to 4 years
Autism Spectrum Disorder (ASD) diagnosis remains behavior-based and the median age of diagnosis is ~52 months, nearly 5 years after its first-trimester origin. Accurate and clinically-translatable early-age di...
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Discovering Common Pathogenic Mechanisms of COVID-19 and Parkinson Disease: An Integrated Bioinformatics Analysis
Coronavirus disease 2019 (COVID-19) has emerged since December 2019 and was later characterized as a pandemic by WHO, imposing a major public health threat globally. Our study aimed to identify common signatur...
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Open AccessLarge scale validation of an early-age eye-tracking biomarker of an autism spectrum disorder subtype
Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances i...
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Open AccessInvestigation and characterization of human gut phageome in advanced liver cirrhosis of defined etiologies
Liver cirrhosis is a major public health problem, accounting for high rates of morbidity and mortality worldwide. The cirrhosis etiology is a broad and essential step in planning a treatment strategy. Many rec...
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Open AccessCorrection to: Moonlighting protein prediction using physico‑chemical and evolutional properties via machine learning methods
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Open AccessPrediction of chemoresistance trait of cancer cell lines using machine learning algorithms and systems biology analysis
Most of the current cancer treatment approaches are invasive along with a broad spectrum of side effects. Furthermore, cancer drug resistance known as chemoresistance is a huge obstacle during treatment. This ...
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Open AccessMoonlighting protein prediction using physico-chemical and evolutional properties via machine learning methods
Moonlighting proteins (MPs) are a subclass of multifunctional proteins in which more than one independent or usually distinct function occurs in a single polypeptide chain. Identification of unknown cellular p...
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Open AccessProteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network
Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures. A total of 144 differently...
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Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
Post-translational modification (PTM) in histone proteins is a covalent modification which mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation, glycosylation, and ADP-ribo...
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Open AccessRepCOOL: computational drug repositioning via integrating heterogeneous biological networks
It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in ...
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Article
Estimation of Suspended Sediment Concentration by M5 Model Tree Based on Hydrological and Moderate Resolution Imaging Spectroradiometer (MODIS) Data
The Estimation of suspended sediment concentration (SSC) is an important factor in river engineering, which is used as an indicator of land-use change, water quality studies, and all projects related to constr...
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Estimation of transverse mixing coefficient in streams using M5, MARS, GA, and PSO approaches
Transverse mixing coefficient is one of the key elements of pollutant in two-dimensional modeling. In this study, four data-driven models, M5 model tree, multivariate adaptive regression splines (MARS), geneti...
