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Article
Open AccessA predictive ensemble classifier for the gene expression diagnosis of ASD at ages 1 to 4 years
Autism Spectrum Disorder (ASD) diagnosis remains behavior-based and the median age of diagnosis is ~52 months, nearly 5 years after its first-trimester origin. Accurate and clinically-translatable early-age di...
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Article
Open AccessElucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration
Human Milk Oligosaccharides (HMOs) are abundant carbohydrates fundamental to infant health and development. Although these oligosaccharides were discovered more than half a century ago, their biosynthesis in t...
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Article
Open AccessLarge scale validation of an early-age eye-tracking biomarker of an autism spectrum disorder subtype
Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances i...
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Article
Open AccessCorrecting for sparsity and interdependence in glycomics by accounting for glycan biosynthesis
Glycans are fundamental cellular building blocks, involved in many organismal functions. Advances in glycomics are elucidating the essential roles of glycans. Still, it remains challenging to properly analyze ...
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Article
Open AccessSystems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy
Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018, two pioneer immunotherapy innovators, Tasuku Honjo and James...
