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Open AccessCorrection: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals
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Open AccessEarly life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia
Childhood trauma (CT) is associated with lower cognitive and social cognitive function in schizophrenia. Recent evidence suggests that the relationship between CT and cognition is mediated by both low-grade sy...
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Open AccessBrain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ ...
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Open AccessCorrection: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals
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Article
Open AccessObesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia....
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Open AccessMicroglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls
Changes in immune function are associated with variance in cognitive functioning in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we examined whether schizophrenia risk-...
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Correction to: Progressive subcortical volume loss in treatment-resistant schizophrenia patients after commencing clozapine treatment
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Open Access1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Hu...
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Progressive subcortical volume loss in treatment-resistant schizophrenia patients after commencing clozapine treatment
The association of antipsychotic medication with abnormal brain morphometry in schizophrenia remains uncertain. This study investigated subcortical morphometric changes 6 months after switching treatment to cl...
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Differences in fractional anisotropy between the patients with schizophrenia and healthy comparison subjects
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Open AccessWhite matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals
Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group perfo...
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Open AccessENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human b...
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Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Prior to and following the publication of this article the authors noted that the complete list of authors was not included in the main article and was only present in Supplementary Table 1. The author list in...
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Open AccessDose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Carriers of large recurrent copy number variants (CNVs) have a higher risk of develo** neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizoph...
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Astrocytic degeneration in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repeated head traumas. Using immunohistochemistry for glial fibrillary acidic protein as a marker, plus automated quantitat...
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Open AccessTest-retest reliability of high spatial resolution diffusion tensor and diffusion kurtosis imaging
We assessed the test-retest reliability of high spatial resolution diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI). Diffusion MRI was acquired using a Siemens 3 Tesla Prisma scanner with 80...
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Axonal disruption in white matter underlying cortical sulcus tau pathology in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first...
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Progressive Brain Atrophy and Cortical Thinning in Schizophrenia after Commencing Clozapine Treatment
Despite evidence that clozapine may be neuroprotective, there are few longitudinal magnetic resonance imaging (MRI) studies that have specifically explored an association between commencement of clozapine trea...
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Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia
Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left ...